Cargando…

Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution

Human gastric pathogen Helicobacter pylori (H. pylori) is the primary risk factor for gastric cancer and is one of the most prevalent carcinogenic infectious agents. Vacuolating cytotoxin A (VacA) is a key virulence factor secreted by H. pylori and induces multiple cellular responses. Although struc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Kaiming, Zhang, Huawei, Li, Shanshan, Pintilie, Grigore D., Mou, Tung-Chung, Gao, Yuanzhu, Zhang, Qinfen, van den Bedem, Henry, Schmid, Michael F., Au, Shannon Wing Ngor, Chiu, Wah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452728/ https://www.ncbi.nlm.nih.gov/pubmed/30894496 http://dx.doi.org/10.1073/pnas.1821959116

Ejemplares similares

Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin
Publicado: (1996)

Cryo-electron Tomography Reveals the Roles of FliY in Helicobacter pylori Flagellar Motor Assembly
por: Lu, Ping, et al.
Publicado: (2022)

Measurement of Atom Resolvability in CryoEM Maps with Q-scores
por: Pintilie, Grigore, et al.
Publicado: (2020)

Validation, analysis and annotation of cryo-EM structures
por: Pintilie, Grigore, et al.
Publicado: (2021)

Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution
por: Zhang, Kaiming, et al.
Publicado: (2019)

Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM
por: Li, Shanshan, et al.
Publicado: (2022)

Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM
por: Zhang, Xiaojing, et al.
Publicado: (2023)

Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM
por: Li, Shanshan, et al.
Publicado: (2023)

Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR–Cas complex revealed by cryo-EM
por: Zhang, Kaiming, et al.
Publicado: (2020)

Resolving individual atoms of protein complex by cryo-electron microscopy
por: Zhang, Kaiming, et al.
Publicado: (2020)

Helicobacter pylori infection: is there circulating vacuolating cytotoxin A or cytotoxin-associated gene A protein?
por: Imoto, Ichiro, et al.
Publicado: (2022)

Evolution of standardization and dissemination of cryo-EM structures and data jointly by the community, PDB, and EMDB
por: Chiu, Wah, et al.
Publicado: (2021)

Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry
por: Guo, Minghui, et al.
Publicado: (2019)

Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures
por: Kappel, Kalli, et al.
Publicado: (2020)

Architecture of the baculovirus nucleocapsid revealed by cryo-EM
por: Jia, Xudong, et al.
Publicado: (2023)

Cryo-EM analysis of Ebola virus nucleocapsid-like assembly
por: Wang, Yan, et al.
Publicado: (2021)

The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk
por: Backert, Steffen, et al.
Publicado: (2010)

Vacuolating cytotoxin A (VacA), a key toxin for Helicobacter pylori pathogenesis
por: Palframan, Samuel L., et al.
Publicado: (2012)

VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets
por: Satoh, Kaneo, et al.
Publicado: (2013)

Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2
por: Zhu, Kongfu, et al.
Publicado: (2022)

DNA Sequence Analysis of South African Helicobacter pylori Vacuolating Cytotoxin Gene (vacA)
por: Tanih, Nicoline F., et al.
Publicado: (2011)

A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori–Induced Metaplasia in the Stomach
por: Winter, Jody A., et al.
Publicado: (2014)

Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells
por: Wang, Li, et al.
Publicado: (2022)

Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia
por: Zhang, Kaiming, et al.
Publicado: (2022)

A 3.4-Å cryo-electron microscopy structure of the human coronavirus spike trimer computationally derived from vitrified NL63 virus particles
por: Zhang, Kaiming, et al.
Publicado: (2020)

Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V(o) complex
por: Roh, Soung-Hun, et al.
Publicado: (2020)

Acid-induced Dissociation of VacA, the Helicobacter pylori Vacuolating Cytotoxin, Reveals Its Pattern of Assembly
por: Cover, Timothy L., et al.
Publicado: (1997)

Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice
por: Suzuki, Hajime, et al.
Publicado: (2019)

Cortactin Promotes Effective AGS Cell Scattering by Helicobacter pylori CagA, but Not Cellular Vacuolization and Apoptosis Induced by the Vacuolating Cytotoxin VacA
por: Sharafutdinov, Irshad, et al.
Publicado: (2021)

Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
por: Ma, Tao, et al.
Publicado: (2023)

Construction and preservation of a stable and highly expressed recombinant Helicobacter pylori vacuolating cytotoxin A with apoptotic activity
por: Yuan, Ling-Zhi, et al.
Publicado: (2021)

Therapeutic properties of Helicobacter pylori-derived vacuolating cytotoxin A in an animal model of chronic allergic airway disease
por: Raspe, Jonas, et al.
Publicado: (2023)

Cryo-EM advances in RNA structure determination
por: Ma, Haiyun, et al.
Publicado: (2022)

Cryo-EM reveals a previously unrecognized structural protein of a dsRNA virus implicated in its extracellular transmission
por: Shao, Qianqian, et al.
Publicado: (2021)

Cryo-EM structures of calcium homeostasis modulator channels in diverse oligomeric assemblies
por: Demura, Kanae, et al.
Publicado: (2020)

CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics
por: Lee, Jane K.J., et al.
Publicado: (2023)

Study of vacuolating cytotoxin A (vacA) genotypes of ulcerogenic and non-ulcerogenic strains of Helicobacter pylori and its association with gastric disease
por: Al-Ouqaili, Mushtak T.S., et al.
Publicado: (2023)

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
por: Xu, Mengyuan, et al.
Publicado: (2023)

CryoEM structure of the mature dengue virus at 3.5-Å resolution
por: Zhang, Xiaokang, et al.
Publicado: (2012)

The active form of Helicobacter pylori vacuolating cytotoxin induces decay‐accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa
por: Kaneko, Kazuyo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_27fv7o8blk2b0kmgcfha5pv4ln