Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy

Studying on subclonal evolution of cancer stem cells can help illustrate how the immune system recognizes tumor cells, leading to subclonal treatment by immune-based therapies. Here, we discuss that cancer subclones derived from the patient’s head and neck squamous cell carcinoma tumor stem cells ca...

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Detalles Bibliográficos
Autores principales: Li, Shengwen Calvin, Ge, Norman N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453126/
https://www.ncbi.nlm.nih.gov/pubmed/30972376
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author Li, Shengwen Calvin
Ge, Norman N
author_facet Li, Shengwen Calvin
Ge, Norman N
author_sort Li, Shengwen Calvin
collection PubMed
description Studying on subclonal evolution of cancer stem cells can help illustrate how the immune system recognizes tumor cells, leading to subclonal treatment by immune-based therapies. Here, we discuss that cancer subclones derived from the patient’s head and neck squamous cell carcinoma tumor stem cells can be used for the screening of personalized antitumor immunotherapy and chemotherapy, to maximize benefits and to minimize the adversary effects, toward personalized or precision medicine. We propose a “wait-and-watch” scheme for monitoring a lifetime cancer stem cell subclonal development evolved with local environments to cancer.
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spelling pubmed-64531262019-04-08 Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy Li, Shengwen Calvin Ge, Norman N Stem Cell Res Ther (Walnut) Article Studying on subclonal evolution of cancer stem cells can help illustrate how the immune system recognizes tumor cells, leading to subclonal treatment by immune-based therapies. Here, we discuss that cancer subclones derived from the patient’s head and neck squamous cell carcinoma tumor stem cells can be used for the screening of personalized antitumor immunotherapy and chemotherapy, to maximize benefits and to minimize the adversary effects, toward personalized or precision medicine. We propose a “wait-and-watch” scheme for monitoring a lifetime cancer stem cell subclonal development evolved with local environments to cancer. 2018-11-29 2018 /pmc/articles/PMC6453126/ /pubmed/30972376 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Article
Li, Shengwen Calvin
Ge, Norman N
Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy
title Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy
title_full Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy
title_fullStr Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy
title_full_unstemmed Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy
title_short Cancer Subclones Derived from the Patient’s Head and Neck Squamous Cell Carcinoma Tumor Stem Cells for the Screening of Personalized Antitumor Immunotherapy and Chemotherapy
title_sort cancer subclones derived from the patient’s head and neck squamous cell carcinoma tumor stem cells for the screening of personalized antitumor immunotherapy and chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453126/
https://www.ncbi.nlm.nih.gov/pubmed/30972376
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