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Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population

BACKGROUND: This study was conducted to explore the effect of known risk factors, focusing on risk factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, in consideration of interaction among East-...

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Autores principales: Lim, Se-Eun, Ahn, HyoJin, Lee, Eun Sook, Kong, Sun-Young, Jung, So-Youn, Lee, Seeyoun, Kang, Han-Sung, Lee, Eun-Gyeong, Han, Jai Hong, Park, Boyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453588/
https://www.ncbi.nlm.nih.gov/pubmed/30993092
http://dx.doi.org/10.15430/JCP.2019.24.1.26
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author Lim, Se-Eun
Ahn, HyoJin
Lee, Eun Sook
Kong, Sun-Young
Jung, So-Youn
Lee, Seeyoun
Kang, Han-Sung
Lee, Eun-Gyeong
Han, Jai Hong
Park, Boyoung
author_facet Lim, Se-Eun
Ahn, HyoJin
Lee, Eun Sook
Kong, Sun-Young
Jung, So-Youn
Lee, Seeyoun
Kang, Han-Sung
Lee, Eun-Gyeong
Han, Jai Hong
Park, Boyoung
author_sort Lim, Se-Eun
collection PubMed
description BACKGROUND: This study was conducted to explore the effect of known risk factors, focusing on risk factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, in consideration of interaction among East-Asian women. METHODS: Case-control study with 2,123 cases and 2,121 controls with mammographic density was conducted. Using the mammographic film, breast density was measured using Breast Imaging-Reporting and Data System. To identify the association of selected reproductive factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, stratified analysis was conducted according to breast density groups and interaction effects was assessed. The results were presented with adjusted OR and 95% CIs. RESULTS: Significant interaction effect between age at first birth and breast density on breast cancer (P = 0.048) was observed. Women with age at first birth ≥ 28 years old showed increased breast cancer risk in extremely dense breast group (≥ 75%) (OR = 1.627, 95% CI = 1.190–2.226). However, women with fatty breast (< 50%) and heterogeneously dense breast (50%–75%) did not show an increased association. Age at menarche, age at menopause, number of children, and family history of breast cancer did not show significant interaction with breast cancer and similar risk patterns were observed. CONCLUSIONS: Age at first birth showed significant interaction with breast density on breast cancer risk. Further studies considering biologically plausable model between exposure, intermediate outcomes and breast cancer risk with prospective design need to be undertaken in East Asian women.
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spelling pubmed-64535882019-04-16 Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population Lim, Se-Eun Ahn, HyoJin Lee, Eun Sook Kong, Sun-Young Jung, So-Youn Lee, Seeyoun Kang, Han-Sung Lee, Eun-Gyeong Han, Jai Hong Park, Boyoung J Cancer Prev Original Article BACKGROUND: This study was conducted to explore the effect of known risk factors, focusing on risk factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, in consideration of interaction among East-Asian women. METHODS: Case-control study with 2,123 cases and 2,121 controls with mammographic density was conducted. Using the mammographic film, breast density was measured using Breast Imaging-Reporting and Data System. To identify the association of selected reproductive factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, stratified analysis was conducted according to breast density groups and interaction effects was assessed. The results were presented with adjusted OR and 95% CIs. RESULTS: Significant interaction effect between age at first birth and breast density on breast cancer (P = 0.048) was observed. Women with age at first birth ≥ 28 years old showed increased breast cancer risk in extremely dense breast group (≥ 75%) (OR = 1.627, 95% CI = 1.190–2.226). However, women with fatty breast (< 50%) and heterogeneously dense breast (50%–75%) did not show an increased association. Age at menarche, age at menopause, number of children, and family history of breast cancer did not show significant interaction with breast cancer and similar risk patterns were observed. CONCLUSIONS: Age at first birth showed significant interaction with breast density on breast cancer risk. Further studies considering biologically plausable model between exposure, intermediate outcomes and breast cancer risk with prospective design need to be undertaken in East Asian women. Korean Society of Cancer Prevention 2019-03 2019-03-30 /pmc/articles/PMC6453588/ /pubmed/30993092 http://dx.doi.org/10.15430/JCP.2019.24.1.26 Text en Copyright © 2019 Korean Society of Cancer Prevention This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lim, Se-Eun
Ahn, HyoJin
Lee, Eun Sook
Kong, Sun-Young
Jung, So-Youn
Lee, Seeyoun
Kang, Han-Sung
Lee, Eun-Gyeong
Han, Jai Hong
Park, Boyoung
Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population
title Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population
title_full Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population
title_fullStr Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population
title_full_unstemmed Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population
title_short Interaction Effect Between Breast Density and Reproductive Factors on Breast Cancer Risk in Korean Population
title_sort interaction effect between breast density and reproductive factors on breast cancer risk in korean population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453588/
https://www.ncbi.nlm.nih.gov/pubmed/30993092
http://dx.doi.org/10.15430/JCP.2019.24.1.26
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