A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face

Leukemia cutis, or infiltration of leukemic cells into the skin, occurs rarely in B-cell acute lymphocytic leukemia (ALL). Herein, we have described a rare, precocious presentation of B-cell ALL presenting as indurated facial plaques in a 69-year-old man. Biopsy of the facial plaques revealed precur...

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Detalles Bibliográficos
Autores principales: Cotter, David G, Hinds, Brian R, Orme, Charisse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453639/
https://www.ncbi.nlm.nih.gov/pubmed/31007979
http://dx.doi.org/10.7759/cureus.4021
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author Cotter, David G
Hinds, Brian R
Orme, Charisse
author_facet Cotter, David G
Hinds, Brian R
Orme, Charisse
author_sort Cotter, David G
collection PubMed
description Leukemia cutis, or infiltration of leukemic cells into the skin, occurs rarely in B-cell acute lymphocytic leukemia (ALL). Herein, we have described a rare, precocious presentation of B-cell ALL presenting as indurated facial plaques in a 69-year-old man. Biopsy of the facial plaques revealed precursor B-cell leukemia/lymphoma in the skin and prompted urgent hematologic-oncologic evaluation. Bone marrow biopsy yielded a final diagnosis of B-cell ALL. The patient underwent induction therapy, and at the last available follow-up, a matched unrelated donor transplant was planned.
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spelling pubmed-64536392019-04-19 A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face Cotter, David G Hinds, Brian R Orme, Charisse Cureus Dermatology Leukemia cutis, or infiltration of leukemic cells into the skin, occurs rarely in B-cell acute lymphocytic leukemia (ALL). Herein, we have described a rare, precocious presentation of B-cell ALL presenting as indurated facial plaques in a 69-year-old man. Biopsy of the facial plaques revealed precursor B-cell leukemia/lymphoma in the skin and prompted urgent hematologic-oncologic evaluation. Bone marrow biopsy yielded a final diagnosis of B-cell ALL. The patient underwent induction therapy, and at the last available follow-up, a matched unrelated donor transplant was planned. Cureus 2019-02-05 /pmc/articles/PMC6453639/ /pubmed/31007979 http://dx.doi.org/10.7759/cureus.4021 Text en Copyright © 2019, Cotter et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Cotter, David G
Hinds, Brian R
Orme, Charisse
A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face
title A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face
title_full A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face
title_fullStr A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face
title_full_unstemmed A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face
title_short A Precocious Presentation of B-cell Acute Lymphoblastic Leukemia as Infiltrated Plaques on the Face
title_sort precocious presentation of b-cell acute lymphoblastic leukemia as infiltrated plaques on the face
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453639/
https://www.ncbi.nlm.nih.gov/pubmed/31007979
http://dx.doi.org/10.7759/cureus.4021
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