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Rapid recurrence of primary gastric choriocarcinoma after complete resection

INTRODUCTION: Primary gastric choriocarcinoma (PGC) is a rare and rapidly invasive tumor. We report a case of PGC diagnosed by endoscopic biopsy and treated with gastrectomy and chemotherapy. PRESENTATION OF CASE: A 78-year-old man was referred to our hospital because esophagogastroduodenoscopy show...

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Autores principales: Hirotsu, Amane, Hiramatsu, Yoshihiro, Kawata, Sanshiro, Matsumoto, Tomohiro, Ozaki, Yusuke, Kikuchi, Hirotoshi, Baba, Megumi, Kamiya, Kinji, Konno, Hiroyuki, Takeuchi, Hiroya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453829/
https://www.ncbi.nlm.nih.gov/pubmed/30959361
http://dx.doi.org/10.1016/j.ijscr.2019.03.045
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author Hirotsu, Amane
Hiramatsu, Yoshihiro
Kawata, Sanshiro
Matsumoto, Tomohiro
Ozaki, Yusuke
Kikuchi, Hirotoshi
Baba, Megumi
Kamiya, Kinji
Konno, Hiroyuki
Takeuchi, Hiroya
author_facet Hirotsu, Amane
Hiramatsu, Yoshihiro
Kawata, Sanshiro
Matsumoto, Tomohiro
Ozaki, Yusuke
Kikuchi, Hirotoshi
Baba, Megumi
Kamiya, Kinji
Konno, Hiroyuki
Takeuchi, Hiroya
author_sort Hirotsu, Amane
collection PubMed
description INTRODUCTION: Primary gastric choriocarcinoma (PGC) is a rare and rapidly invasive tumor. We report a case of PGC diagnosed by endoscopic biopsy and treated with gastrectomy and chemotherapy. PRESENTATION OF CASE: A 78-year-old man was referred to our hospital because esophagogastroduodenoscopy showed a tumor at the fornix of the stomach. Pathologic examination of biopsy specimens revealed choriocarcinoma. Abdominal computed tomography (CT) revealed no enlarged abdominal lymph nodes or distant metastases. Robot-assisted total gastrectomy with spleen-preserving D2 lymphadenectomy was performed on the basis of a diagnosis of cT2N0M0, stage cIB PGC. The pathologic diagnosis was pT2, ly0, v1, pN0, PM0, DM0, stage pIB PGC. The postoperative course was uneventful, and the patient was followed carefully without adjuvant chemotherapy. Three months after gastrectomy, blood tests indicated that serum β-human chorionic gonadotropin (β-hCG) levels had increased, and CT revealed multiple liver metastases. The patient underwent a standard nongestational choriocarcinoma chemotherapy regimen with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine. Although β-hCG levels temporarily decreased with chemotherapy, the patient experienced tumor recurrence with ascites and his serological test demonstrated an elevated level of β-hCG (120 ng/mL). The patient died 10 months postoperatively. CONCLUSION: We report a case of stage pIB PGC with poor prognosis, recurring at only 3 months postoperatively despite curative surgery and chemotherapy.
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spelling pubmed-64538292019-04-19 Rapid recurrence of primary gastric choriocarcinoma after complete resection Hirotsu, Amane Hiramatsu, Yoshihiro Kawata, Sanshiro Matsumoto, Tomohiro Ozaki, Yusuke Kikuchi, Hirotoshi Baba, Megumi Kamiya, Kinji Konno, Hiroyuki Takeuchi, Hiroya Int J Surg Case Rep Article INTRODUCTION: Primary gastric choriocarcinoma (PGC) is a rare and rapidly invasive tumor. We report a case of PGC diagnosed by endoscopic biopsy and treated with gastrectomy and chemotherapy. PRESENTATION OF CASE: A 78-year-old man was referred to our hospital because esophagogastroduodenoscopy showed a tumor at the fornix of the stomach. Pathologic examination of biopsy specimens revealed choriocarcinoma. Abdominal computed tomography (CT) revealed no enlarged abdominal lymph nodes or distant metastases. Robot-assisted total gastrectomy with spleen-preserving D2 lymphadenectomy was performed on the basis of a diagnosis of cT2N0M0, stage cIB PGC. The pathologic diagnosis was pT2, ly0, v1, pN0, PM0, DM0, stage pIB PGC. The postoperative course was uneventful, and the patient was followed carefully without adjuvant chemotherapy. Three months after gastrectomy, blood tests indicated that serum β-human chorionic gonadotropin (β-hCG) levels had increased, and CT revealed multiple liver metastases. The patient underwent a standard nongestational choriocarcinoma chemotherapy regimen with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine. Although β-hCG levels temporarily decreased with chemotherapy, the patient experienced tumor recurrence with ascites and his serological test demonstrated an elevated level of β-hCG (120 ng/mL). The patient died 10 months postoperatively. CONCLUSION: We report a case of stage pIB PGC with poor prognosis, recurring at only 3 months postoperatively despite curative surgery and chemotherapy. Elsevier 2019-03-30 /pmc/articles/PMC6453829/ /pubmed/30959361 http://dx.doi.org/10.1016/j.ijscr.2019.03.045 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hirotsu, Amane
Hiramatsu, Yoshihiro
Kawata, Sanshiro
Matsumoto, Tomohiro
Ozaki, Yusuke
Kikuchi, Hirotoshi
Baba, Megumi
Kamiya, Kinji
Konno, Hiroyuki
Takeuchi, Hiroya
Rapid recurrence of primary gastric choriocarcinoma after complete resection
title Rapid recurrence of primary gastric choriocarcinoma after complete resection
title_full Rapid recurrence of primary gastric choriocarcinoma after complete resection
title_fullStr Rapid recurrence of primary gastric choriocarcinoma after complete resection
title_full_unstemmed Rapid recurrence of primary gastric choriocarcinoma after complete resection
title_short Rapid recurrence of primary gastric choriocarcinoma after complete resection
title_sort rapid recurrence of primary gastric choriocarcinoma after complete resection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453829/
https://www.ncbi.nlm.nih.gov/pubmed/30959361
http://dx.doi.org/10.1016/j.ijscr.2019.03.045
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