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DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells

β-amyloid (Aβ) plays an essential role in the pathogenesis of Alzheimer’s disease (AD). Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is indispensable for Aβ production, and knockout of BACE1 has no overt phenotypes in mouse. Thus, fine modulation of BACE1 may be a safe and effective...

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Detalles Bibliográficos
Autores principales:	Xiang, Jun, Zhang, Wen, Cai, Xiao-Fang, Cai, Min, Yu, Zhong-Hai, Yang, Feng, Zhu, Wen, Li, Xiang-Ting, Wu, Ting, Zhang, Jing-Si, Cai, Ding-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453838/ https://www.ncbi.nlm.nih.gov/pubmed/30959405 http://dx.doi.org/10.1016/j.omtn.2019.02.025

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