Cargando…

Ceramides in Parkinson’s Disease: From Recent Evidence to New Hypotheses

Ceramides (Cer) constitute a class of lipids present in the cell membranes where they act as structural components, but they can also work as signaling molecules. Increasing genetic and biochemical evidence supports a link between deregulation of ceramide metabolism in the brain and neurodegeneratio...

Descripción completa

Detalles Bibliográficos
Autores principales: Plotegher, Nicoletta, Bubacco, Luigi, Greggio, Elisa, Civiero, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454043/
https://www.ncbi.nlm.nih.gov/pubmed/31001082
http://dx.doi.org/10.3389/fnins.2019.00330
Descripción
Sumario:Ceramides (Cer) constitute a class of lipids present in the cell membranes where they act as structural components, but they can also work as signaling molecules. Increasing genetic and biochemical evidence supports a link between deregulation of ceramide metabolism in the brain and neurodegeneration. Here, we provide an overview of the genes and cellular pathways that link Cer with Parkinson’s disease and discuss how ceramide pathobiology is gaining increasing interest in the understanding of the pathological mechanisms that contribute to the disease and in the clinical and therapeutic side.