Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress

Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintain proteostasis. Here, we report that hippocampal c...

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Detalles Bibliográficos
Autores principales: Chakraborty, Debapriya, Felzen, Vanessa, Hiebel, Christof, Stürner, Elisabeth, Perumal, Natarajan, Manicam, Caroline, Sehn, Elisabeth, Grus, Franz, Wolfrum, Uwe, Behl, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454062/
https://www.ncbi.nlm.nih.gov/pubmed/30959460
http://dx.doi.org/10.1016/j.redox.2019.101181

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