The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer

Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially havin...

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Autores principales: Wang, Hao-fan, Wang, Sha-sha, Tang, Ya-Jie, Chen, Yu, Zheng, Min, Tang, Ya-ling, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454067/
https://www.ncbi.nlm.nih.gov/pubmed/31001266
http://dx.doi.org/10.3389/fimmu.2019.00653
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author Wang, Hao-fan
Wang, Sha-sha
Tang, Ya-Jie
Chen, Yu
Zheng, Min
Tang, Ya-ling
Liang, Xin-hua
author_facet Wang, Hao-fan
Wang, Sha-sha
Tang, Ya-Jie
Chen, Yu
Zheng, Min
Tang, Ya-ling
Liang, Xin-hua
author_sort Wang, Hao-fan
collection PubMed
description Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts.
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spelling pubmed-64540672019-04-18 The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer Wang, Hao-fan Wang, Sha-sha Tang, Ya-Jie Chen, Yu Zheng, Min Tang, Ya-ling Liang, Xin-hua Front Immunol Immunology Patients with human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have remarkably better prognosis, which differs from HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) with respect to clinical, genomic, molecular, and immunological aspects, especially having the characteristics of high levels of immune cell infiltration and high degrees of immunosuppression. This review will summarize immune evasion mechanisms in HPV-positive HNSCC, analyze the host various immune responses to HPV and abundant numbers of infiltrating immune cell, and discuss the differences between HPV-positive HNSCC with cervical cancer. A deeper understanding of the immune landscape will help new concepts to emerge in immune-checkpoint oncology, which might be a valuable add-on to established concepts. Frontiers Media S.A. 2019-04-02 /pmc/articles/PMC6454067/ /pubmed/31001266 http://dx.doi.org/10.3389/fimmu.2019.00653 Text en Copyright © 2019 Wang, Wang, Tang, Chen, Zheng, Tang and Liang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Hao-fan
Wang, Sha-sha
Tang, Ya-Jie
Chen, Yu
Zheng, Min
Tang, Ya-ling
Liang, Xin-hua
The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
title The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
title_full The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
title_fullStr The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
title_full_unstemmed The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
title_short The Double-Edged Sword—How Human Papillomaviruses Interact With Immunity in Head and Neck Cancer
title_sort double-edged sword—how human papillomaviruses interact with immunity in head and neck cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454067/
https://www.ncbi.nlm.nih.gov/pubmed/31001266
http://dx.doi.org/10.3389/fimmu.2019.00653
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