Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway

Glioblastoma (GBM) is the most common type of malignant brain tumor in adults. We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human glioblastoma cell death. Its mechanism of action and the interaction of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Doan, Phuong, Musa, Aliyu, Candeias, Nuno R., Emmert-Streib, Frank, Yli-Harja, Olli, Kandhavelu, Meenakshisundaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454069/
https://www.ncbi.nlm.nih.gov/pubmed/31001122
http://dx.doi.org/10.3389/fphar.2019.00330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454069/
https://www.ncbi.nlm.nih.gov/pubmed/31001122
http://dx.doi.org/10.3389/fphar.2019.00330

Ejemplares similares