S-Nitrosylation of α1-Antitrypsin Triggers Macrophages Toward Inflammatory Phenotype and Enhances Intra-Cellular Bacteria Elimination

Background: Human α1-antitrypsin (hAAT) is a circulating anti-inflammatory serine-protease inhibitor that rises during acute phase responses. in vivo, hAAT reduces bacterial load, without directly inhibiting bacterial growth. In conditions of excess nitric-oxide (NO), hAAT undergoes S-nitrosylation...

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Detalles Bibliográficos
Autores principales: Kaner, Ziv, Engelman, Rotem, Schuster, Ronen, Rider, Peleg, Greenberg, David, Av-Gay, Yossef, Benhar, Moran, Lewis, Eli C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454134/
https://www.ncbi.nlm.nih.gov/pubmed/31001247
http://dx.doi.org/10.3389/fimmu.2019.00590

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