Cargando…

Comorbidities as Risk Factors for Acute and Recurrent Erysipelas

BACKGROUND: Erysipelas is a common infectious skin disease. A typical feature of erysipelas, especially on the lower limbs, is the tendency to reoccur and the study aimed to define the comorbidities associated with it. AIM: We aimed to investigate systemic and local comorbidities in patients diagnos...

Descripción completa

Detalles Bibliográficos
Autores principales: Brishkoska-Boshkovski, Vesna, Kondova-Topuzovska, Irena, Damevska, Katerina, Petrov, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454161/
https://www.ncbi.nlm.nih.gov/pubmed/30976336
http://dx.doi.org/10.3889/oamjms.2019.214
_version_ 1783409519175401472
author Brishkoska-Boshkovski, Vesna
Kondova-Topuzovska, Irena
Damevska, Katerina
Petrov, Andrej
author_facet Brishkoska-Boshkovski, Vesna
Kondova-Topuzovska, Irena
Damevska, Katerina
Petrov, Andrej
author_sort Brishkoska-Boshkovski, Vesna
collection PubMed
description BACKGROUND: Erysipelas is a common infectious skin disease. A typical feature of erysipelas, especially on the lower limbs, is the tendency to reoccur and the study aimed to define the comorbidities associated with it. AIM: We aimed to investigate systemic and local comorbidities in patients diagnosed with erysipelas on the lower limbs. MATERIAL AND METHODS: We conducted a retrospectively-prospective, population-based cohort study which included all patients diagnosed with erysipelas on the lower limbs, during two years. Patients were divided into two groups: patients with first episode and patients with recurrent erysipelas. These two groups were compared, with particular emphasis on systemic and local comorbidities. RESULTS: The study included 313 patients, of which 187 with the first episode of erysipelas and 126 with a recurrent. Regarding the analyzed systemic risk factors, the recurrent erysipelas was significantly associated with obesity (p < 0.0001), insulin dependent diabetes mellitus (p = 0.0015), history of malignant disease (p = 0.02) and tonsillectomy (p = 0.000001). For a p-value < 0.0001, significantly more frequent finding of peripheral arterial occlusive disease, chronic oedema/lymphoedema, fungal infections of the affected leg and chronic ulcer was confirmed in recurrent erysipelas. Neuropathy had 23% of the recurrent cases and 8.6% in patients without recurrence, and the difference was found to be significant for p = 0.0003. The only dissection of the lymph nodes was found more frequently in recurrent erysipelas (p = 0.017), but no associations with other analysed local surgery on the affected leg. Patients with recurrent erysipelas had ipsilateral coexisting dermatitis p = 0.00003 significantly more frequent. Minor trauma often preceded the first episode of erysipelas p = 0.005. CONCLUSION: Identification and treatment of modifiable risk factors are expected to reduce the risk of a subsequent episode of erysipelas on the lower limbs.
format Online
Article
Text
id pubmed-6454161
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Republic of Macedonia
record_format MEDLINE/PubMed
spelling pubmed-64541612019-04-11 Comorbidities as Risk Factors for Acute and Recurrent Erysipelas Brishkoska-Boshkovski, Vesna Kondova-Topuzovska, Irena Damevska, Katerina Petrov, Andrej Open Access Maced J Med Sci Clinical Science BACKGROUND: Erysipelas is a common infectious skin disease. A typical feature of erysipelas, especially on the lower limbs, is the tendency to reoccur and the study aimed to define the comorbidities associated with it. AIM: We aimed to investigate systemic and local comorbidities in patients diagnosed with erysipelas on the lower limbs. MATERIAL AND METHODS: We conducted a retrospectively-prospective, population-based cohort study which included all patients diagnosed with erysipelas on the lower limbs, during two years. Patients were divided into two groups: patients with first episode and patients with recurrent erysipelas. These two groups were compared, with particular emphasis on systemic and local comorbidities. RESULTS: The study included 313 patients, of which 187 with the first episode of erysipelas and 126 with a recurrent. Regarding the analyzed systemic risk factors, the recurrent erysipelas was significantly associated with obesity (p < 0.0001), insulin dependent diabetes mellitus (p = 0.0015), history of malignant disease (p = 0.02) and tonsillectomy (p = 0.000001). For a p-value < 0.0001, significantly more frequent finding of peripheral arterial occlusive disease, chronic oedema/lymphoedema, fungal infections of the affected leg and chronic ulcer was confirmed in recurrent erysipelas. Neuropathy had 23% of the recurrent cases and 8.6% in patients without recurrence, and the difference was found to be significant for p = 0.0003. The only dissection of the lymph nodes was found more frequently in recurrent erysipelas (p = 0.017), but no associations with other analysed local surgery on the affected leg. Patients with recurrent erysipelas had ipsilateral coexisting dermatitis p = 0.00003 significantly more frequent. Minor trauma often preceded the first episode of erysipelas p = 0.005. CONCLUSION: Identification and treatment of modifiable risk factors are expected to reduce the risk of a subsequent episode of erysipelas on the lower limbs. Republic of Macedonia 2019-03-15 /pmc/articles/PMC6454161/ /pubmed/30976336 http://dx.doi.org/10.3889/oamjms.2019.214 Text en Copyright: © 2019 Vesna Brishkoska-Boshkovski, Irena Kondova-Topuzovska, Katerina Damevska, Andrej Petrov http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Clinical Science
Brishkoska-Boshkovski, Vesna
Kondova-Topuzovska, Irena
Damevska, Katerina
Petrov, Andrej
Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
title Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
title_full Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
title_fullStr Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
title_full_unstemmed Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
title_short Comorbidities as Risk Factors for Acute and Recurrent Erysipelas
title_sort comorbidities as risk factors for acute and recurrent erysipelas
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454161/
https://www.ncbi.nlm.nih.gov/pubmed/30976336
http://dx.doi.org/10.3889/oamjms.2019.214
work_keys_str_mv AT brishkoskaboshkovskivesna comorbiditiesasriskfactorsforacuteandrecurrenterysipelas
AT kondovatopuzovskairena comorbiditiesasriskfactorsforacuteandrecurrenterysipelas
AT damevskakaterina comorbiditiesasriskfactorsforacuteandrecurrenterysipelas
AT petrovandrej comorbiditiesasriskfactorsforacuteandrecurrenterysipelas