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Synthesis and Pharmacological Screening of Pyridopyrimidines as Effective Anti‐Diarrheal Agents through the Suppression of Cyclic Nucleotide Accumulation

The increased levels of cyclic nucleotides (cGMP and cAMP) in enterocytes trigger intracellular mechanisms of ion and fluid secretion into the lumen, causing secretory diarrhea. Twelve novel pyridopyrimidines derived from 5‐(3,5‐bistrifluoromethylphenyl)‐1,3‐dimethyl‐5,11‐dihydro‐1H‐indeno[2,1 : 5,6...

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Detalles Bibliográficos
Autores principales:	Zaminelli, Tiago, Magli, Elisa, Frecentese, Francesco, Lescano, Caroline H., Campos, Rafael, Saccone, Irene, Corvino, Angela, Di Vaio, Paola, Giordano, Flavia, Luciano, Paolo, Fiorino, Ferdinando, Perissutti, Elisa, Santagada, Vincenzo, Severino, Beatrice, Caliendo, Giuseppe, De Nucci, Gilberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454219/ https://www.ncbi.nlm.nih.gov/pubmed/31008011 http://dx.doi.org/10.1002/open.201900060

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