The selective TrkA agonist, gambogic amide, promotes osteoblastic differentiation and improves fracture healing in mice

OBJECTIVES: To study effects of the selective TrkA agonist, gambogic amide (GA), on fracture healing in mice and on an osteoprogenitor cell line in vitro. METHODS: Mice were given bilateral fibular fractures and treated for two weeks with vehicle or 1 mg/kg/day GA and euthanized at 14-, 21-, and 42-...

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Detalles Bibliográficos
Autores principales: Johnstone, Maddison R., Brady, Rhys D., Schuijers, Johannes A., Church, Jarrod E., Orr, David, Quinn, Julian M.W., McDonald, Stuart J., Grills, Brian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Society of Musculoskeletal and Neuronal Interactions 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454248/
https://www.ncbi.nlm.nih.gov/pubmed/30839307

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