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Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes
BACKGROUND: Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients after unilateral nephrectomy. METHODS: Totally 193 renal cancer patients, includin...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454684/ https://www.ncbi.nlm.nih.gov/pubmed/30961555 http://dx.doi.org/10.1186/s12885-019-5414-x |
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author | Niu, Sheng-Wen Liang, Peir-In Lin, Ming-Yen Yeh, Shih-Meng Zhen, Yen-Yi Chang, Yu-Han Huang, Pin-Chia Hung, Chi-Chi Kuo, I-Ching Lin, Hugo You-Hsien Kuo, Mei-Chuan Li, Wei-Ming Huang, Chun-Nung Wu, Wen-Jeng Chen, Li-Tzong Chiu, Yi-Wen Hwang, Shang-Jyh |
author_facet | Niu, Sheng-Wen Liang, Peir-In Lin, Ming-Yen Yeh, Shih-Meng Zhen, Yen-Yi Chang, Yu-Han Huang, Pin-Chia Hung, Chi-Chi Kuo, I-Ching Lin, Hugo You-Hsien Kuo, Mei-Chuan Li, Wei-Ming Huang, Chun-Nung Wu, Wen-Jeng Chen, Li-Tzong Chiu, Yi-Wen Hwang, Shang-Jyh |
author_sort | Niu, Sheng-Wen |
collection | PubMed |
description | BACKGROUND: Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients after unilateral nephrectomy. METHODS: Totally 193 renal cancer patients, including 132 UTUC and 61 RCC, were studied to clarify whether the pathological changes of the kidney remnant removed from nephrectomy and the clinical factors might predict the risk of ESRD. Renal tubulointerstitial (TI) score and global glomerulosclerosis (GGS) rate were examined by one pathologist and two nephrologists independently under same histopathological criteria. RESULTS: The glomerular filtration rates at the time of surgery were lower in UTUC than RCC groups (p < 0.001). Average GGS score and average TI rate were higher in UTUC than in RCC groups (p < 0.001; p < 0.001). Competitive risk factor analysis revealed that abnormal GGS rate not related to age, predominant in UTUC with pre-existing renal function impairment, was a histopathological predictor of poor renal outcomes (creatinine doubling or ESRD) within 5 years in UTUC patients. CONCLUSION: Pre-existing renal function and pathological change of kidney remnant in both UTUC and RCC have the value for prediction of renal outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-019-5414-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6454684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64546842019-04-19 Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes Niu, Sheng-Wen Liang, Peir-In Lin, Ming-Yen Yeh, Shih-Meng Zhen, Yen-Yi Chang, Yu-Han Huang, Pin-Chia Hung, Chi-Chi Kuo, I-Ching Lin, Hugo You-Hsien Kuo, Mei-Chuan Li, Wei-Ming Huang, Chun-Nung Wu, Wen-Jeng Chen, Li-Tzong Chiu, Yi-Wen Hwang, Shang-Jyh BMC Cancer Research Article BACKGROUND: Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients after unilateral nephrectomy. METHODS: Totally 193 renal cancer patients, including 132 UTUC and 61 RCC, were studied to clarify whether the pathological changes of the kidney remnant removed from nephrectomy and the clinical factors might predict the risk of ESRD. Renal tubulointerstitial (TI) score and global glomerulosclerosis (GGS) rate were examined by one pathologist and two nephrologists independently under same histopathological criteria. RESULTS: The glomerular filtration rates at the time of surgery were lower in UTUC than RCC groups (p < 0.001). Average GGS score and average TI rate were higher in UTUC than in RCC groups (p < 0.001; p < 0.001). Competitive risk factor analysis revealed that abnormal GGS rate not related to age, predominant in UTUC with pre-existing renal function impairment, was a histopathological predictor of poor renal outcomes (creatinine doubling or ESRD) within 5 years in UTUC patients. CONCLUSION: Pre-existing renal function and pathological change of kidney remnant in both UTUC and RCC have the value for prediction of renal outcomes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-019-5414-x) contains supplementary material, which is available to authorized users. BioMed Central 2019-04-08 /pmc/articles/PMC6454684/ /pubmed/30961555 http://dx.doi.org/10.1186/s12885-019-5414-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Niu, Sheng-Wen Liang, Peir-In Lin, Ming-Yen Yeh, Shih-Meng Zhen, Yen-Yi Chang, Yu-Han Huang, Pin-Chia Hung, Chi-Chi Kuo, I-Ching Lin, Hugo You-Hsien Kuo, Mei-Chuan Li, Wei-Ming Huang, Chun-Nung Wu, Wen-Jeng Chen, Li-Tzong Chiu, Yi-Wen Hwang, Shang-Jyh Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
title | Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
title_full | Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
title_fullStr | Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
title_full_unstemmed | Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
title_short | Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
title_sort | predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454684/ https://www.ncbi.nlm.nih.gov/pubmed/30961555 http://dx.doi.org/10.1186/s12885-019-5414-x |
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