Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study

We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Labor...

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Autores principales: Kofi, Boniface, Mossoro-Kpinde, Christian Diamant, Mboumba Bouassa, Ralph-Sydney, Péré, Hélène, Robin, Leman, Gresenguet, Gérard, Bélec, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454762/
https://www.ncbi.nlm.nih.gov/pubmed/31007710
http://dx.doi.org/10.1186/s13027-019-0225-x
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author Kofi, Boniface
Mossoro-Kpinde, Christian Diamant
Mboumba Bouassa, Ralph-Sydney
Péré, Hélène
Robin, Leman
Gresenguet, Gérard
Bélec, Laurent
author_facet Kofi, Boniface
Mossoro-Kpinde, Christian Diamant
Mboumba Bouassa, Ralph-Sydney
Péré, Hélène
Robin, Leman
Gresenguet, Gérard
Bélec, Laurent
author_sort Kofi, Boniface
collection PubMed
description We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic.
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spelling pubmed-64547622019-04-19 Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study Kofi, Boniface Mossoro-Kpinde, Christian Diamant Mboumba Bouassa, Ralph-Sydney Péré, Hélène Robin, Leman Gresenguet, Gérard Bélec, Laurent Infect Agent Cancer Letter to the Editor We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de Biologie Clinique et de Santé Publique of Bangui, the capital city of the Central African Republic. One oropharyngeal squamous cell carcinoma sample was positive for HPV type 16. The overall HPV prevalence in HNC biopsies was 0.74% (95% CI: 0.0–2.2). Among the 29 cervical cancer samples, 19 (65.5%; 95% CI: 48.2–82.8) were positive for HPV. These results indicate that HNC are infrequently associated with HPV infection in the Central African Republic. BioMed Central 2019-04-08 /pmc/articles/PMC6454762/ /pubmed/31007710 http://dx.doi.org/10.1186/s13027-019-0225-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Kofi, Boniface
Mossoro-Kpinde, Christian Diamant
Mboumba Bouassa, Ralph-Sydney
Péré, Hélène
Robin, Leman
Gresenguet, Gérard
Bélec, Laurent
Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_full Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_fullStr Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_full_unstemmed Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_short Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study
title_sort infrequent detection of human papillomavirus infection in head and neck cancers in the central african republic: a retrospective study
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454762/
https://www.ncbi.nlm.nih.gov/pubmed/31007710
http://dx.doi.org/10.1186/s13027-019-0225-x
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