Valproic acid exhibits anti-tumor activity selectively against EGFR/ErbB2/ErbB3-coexpressing pancreatic cancer via induction of ErbB family members-targeting microRNAs

BACKGROUND: Deregulated ErbB signaling plays an important role in tumorigenesis of pancreatic cancer. However, patients with pancreatic cancer benefit little from current existed therapies targeting the ErbB signaling. Here, we explore the potential anti-tumor activity of Valproic acid against pancr...

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Detalles Bibliográficos
Autores principales: Lin, Tingting, Ren, Qun, Zuo, Weimin, Jia, Ruxue, Xie, Linhui, Lin, Rong, Zhao, Hu, Chen, Jin, Lei, Yan, Wang, Ping, Dong, Huiyue, Huang, Lianghu, Cai, Jinquan, Peng, Yonghai, Yu, Zongyang, Tan, Jianming, Wang, Shuiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454766/
https://www.ncbi.nlm.nih.gov/pubmed/30961642
http://dx.doi.org/10.1186/s13046-019-1160-9

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