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Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)

BACKGROUND: This work describes a chemical study of the essential oil from leaves of Xylopia ochrantha, an endemic Annonaceae species from Brazil, and its activity against Biomphalaria species. Considering its poor solubility in aqueous medium, the essential oil was nanoemulsified to evaluate its ac...

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Autores principales: Araújo, Fernanda de Paula, de Albuquerque, Ricardo Diego Duarte Galhardo, Rangel, Leonardo da Silva, Caldas, Gabriel Rocha, Tietbohl, Luís Armando Cândido, Santos, Marcelo Guerra, Ricci-Júnior, Eduardo, Thiengo, Silvana, Fernandez, Monica Ammon, dos Santos, José Augusto Albuquerque, Faria, Robson Xavier, Rocha, Leandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454853/
https://www.ncbi.nlm.nih.gov/pubmed/30970079
http://dx.doi.org/10.1590/0074-02760180489
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author Araújo, Fernanda de Paula
de Albuquerque, Ricardo Diego Duarte Galhardo
Rangel, Leonardo da Silva
Caldas, Gabriel Rocha
Tietbohl, Luís Armando Cândido
Santos, Marcelo Guerra
Ricci-Júnior, Eduardo
Thiengo, Silvana
Fernandez, Monica Ammon
dos Santos, José Augusto Albuquerque
Faria, Robson Xavier
Rocha, Leandro
author_facet Araújo, Fernanda de Paula
de Albuquerque, Ricardo Diego Duarte Galhardo
Rangel, Leonardo da Silva
Caldas, Gabriel Rocha
Tietbohl, Luís Armando Cândido
Santos, Marcelo Guerra
Ricci-Júnior, Eduardo
Thiengo, Silvana
Fernandez, Monica Ammon
dos Santos, José Augusto Albuquerque
Faria, Robson Xavier
Rocha, Leandro
author_sort Araújo, Fernanda de Paula
collection PubMed
description BACKGROUND: This work describes a chemical study of the essential oil from leaves of Xylopia ochrantha, an endemic Annonaceae species from Brazil, and its activity against Biomphalaria species. Considering its poor solubility in aqueous medium, the essential oil was nanoemulsified to evaluate its action on controlling some mollusc species of genus Biomphalaria, snail hosts of Schistosoma mansoni that causes schistosomiasis, which mainly affects tropical and subtropical countries. OBJECTIVES: The main aims of this work were to analyse the chemical composition of essential oil from X. ochrantha, and to evaluate the effect of its nanoemulsion on molluscs of genus Biomphalaria and their oviposition. METHODS: Chemical analysis was performed by gas chromatography coupled to mass spectrometry. Nanoemulsions were prepared by a low energy method and characterised by particle size and polydispersity index. Biological assays evaluating the mortality of adult species of B. glabrata, B. straminea and B. tenagophila and their ovipositions upon contact with the most stable nanoemulsion during 24 and 48 h were performed. FINDINGS: Chemical analysis by mass spectrometry revealed the majority presence of bicyclogermacrene and germacrene D in the essential oil. The formulation with a hydrophilic-lipophilic balance (HLB) of 9.26 was the most suitable for the oil delivery system. This nanoemulsion caused the mortality in B. tenagophila, B. straminea and B. glabarata of different sizes at levels ranging from 50 to 100% in 48 h. Additionally, the formulation could inhibit the development of deposited eggs. CONCLUSION: Thus, these results suggest the use of nanoemulsified essential oil from X. ochrantha as a possible alternative in controlling some Biomphalaria species involved in the schistosomiasis cycle.
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spelling pubmed-64548532019-04-18 Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts) Araújo, Fernanda de Paula de Albuquerque, Ricardo Diego Duarte Galhardo Rangel, Leonardo da Silva Caldas, Gabriel Rocha Tietbohl, Luís Armando Cândido Santos, Marcelo Guerra Ricci-Júnior, Eduardo Thiengo, Silvana Fernandez, Monica Ammon dos Santos, José Augusto Albuquerque Faria, Robson Xavier Rocha, Leandro Mem Inst Oswaldo Cruz Original Articles BACKGROUND: This work describes a chemical study of the essential oil from leaves of Xylopia ochrantha, an endemic Annonaceae species from Brazil, and its activity against Biomphalaria species. Considering its poor solubility in aqueous medium, the essential oil was nanoemulsified to evaluate its action on controlling some mollusc species of genus Biomphalaria, snail hosts of Schistosoma mansoni that causes schistosomiasis, which mainly affects tropical and subtropical countries. OBJECTIVES: The main aims of this work were to analyse the chemical composition of essential oil from X. ochrantha, and to evaluate the effect of its nanoemulsion on molluscs of genus Biomphalaria and their oviposition. METHODS: Chemical analysis was performed by gas chromatography coupled to mass spectrometry. Nanoemulsions were prepared by a low energy method and characterised by particle size and polydispersity index. Biological assays evaluating the mortality of adult species of B. glabrata, B. straminea and B. tenagophila and their ovipositions upon contact with the most stable nanoemulsion during 24 and 48 h were performed. FINDINGS: Chemical analysis by mass spectrometry revealed the majority presence of bicyclogermacrene and germacrene D in the essential oil. The formulation with a hydrophilic-lipophilic balance (HLB) of 9.26 was the most suitable for the oil delivery system. This nanoemulsion caused the mortality in B. tenagophila, B. straminea and B. glabarata of different sizes at levels ranging from 50 to 100% in 48 h. Additionally, the formulation could inhibit the development of deposited eggs. CONCLUSION: Thus, these results suggest the use of nanoemulsified essential oil from X. ochrantha as a possible alternative in controlling some Biomphalaria species involved in the schistosomiasis cycle. Instituto Oswaldo Cruz, Ministério da Saúde 2019-04-08 /pmc/articles/PMC6454853/ /pubmed/30970079 http://dx.doi.org/10.1590/0074-02760180489 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Original Articles
Araújo, Fernanda de Paula
de Albuquerque, Ricardo Diego Duarte Galhardo
Rangel, Leonardo da Silva
Caldas, Gabriel Rocha
Tietbohl, Luís Armando Cândido
Santos, Marcelo Guerra
Ricci-Júnior, Eduardo
Thiengo, Silvana
Fernandez, Monica Ammon
dos Santos, José Augusto Albuquerque
Faria, Robson Xavier
Rocha, Leandro
Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)
title Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)
title_full Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)
title_fullStr Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)
title_full_unstemmed Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)
title_short Nanoemulsion containing essential oil from Xylopia ochrantha Mart. produces molluscicidal effects against different species of Biomphalaria (Schistosoma hosts)
title_sort nanoemulsion containing essential oil from xylopia ochrantha mart. produces molluscicidal effects against different species of biomphalaria (schistosoma hosts)
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454853/
https://www.ncbi.nlm.nih.gov/pubmed/30970079
http://dx.doi.org/10.1590/0074-02760180489
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