Incorporation of RG1 epitope concatemers into a self-adjuvanting Flagellin-L2 vaccine broaden durable protection against cutaneous challenge with diverse human papillomavirus genotypes

AIM: To achieve durable and broad protection against human papillomaviruses by vaccination with multimers of minor capsid antigen L2 using self-adjuvanting fusions with the toll-like receptor-5 (TLR5) ligand bacterial flagellin (Fla) instead of co-formulation with alum. METHODS: Fla fusions with L2...

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Detalles Bibliográficos
Autores principales: Kalnin, Kirill, Chivukula, Sudha, Tibbitts, Timothy, Yan, Yanhua, Stegalkina, Svetlana, Shen, Lihua, Cieszynski, Jacqueline, Costa, Victor, Sabharwal, Robert, Anderson, Stephen F., Christensen, Neil, Jagu, Subhashini, Roden, Richard B.S., Kleanthous, Harry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454882/
https://www.ncbi.nlm.nih.gov/pubmed/28778613
http://dx.doi.org/10.1016/j.vaccine.2017.07.086

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