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Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation

INTRODUCTION: Gliomas are the most common brain tumors in adults originating from the glial cells. Glioblastoma multiforme is the most malignant and frequent among all gliomas. In recent years, the antibody Mindbomb Homolog-1 (MIB-1) has evolved as a measure of the proliferative nature of the glial...

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Autores principales: Krishnan, Shyam Sundar, Muthiah, Shanmugam, Rao, Shilpa, Salem, Suganthi Srinivasan, Madabhushi, Vasudevan Chakravarthy, Mahadevan, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454943/
https://www.ncbi.nlm.nih.gov/pubmed/31001003
http://dx.doi.org/10.4103/jnrp.jnrp_374_18
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author Krishnan, Shyam Sundar
Muthiah, Shanmugam
Rao, Shilpa
Salem, Suganthi Srinivasan
Madabhushi, Vasudevan Chakravarthy
Mahadevan, Anita
author_facet Krishnan, Shyam Sundar
Muthiah, Shanmugam
Rao, Shilpa
Salem, Suganthi Srinivasan
Madabhushi, Vasudevan Chakravarthy
Mahadevan, Anita
author_sort Krishnan, Shyam Sundar
collection PubMed
description INTRODUCTION: Gliomas are the most common brain tumors in adults originating from the glial cells. Glioblastoma multiforme is the most malignant and frequent among all gliomas. In recent years, the antibody Mindbomb Homolog-1 (MIB-1) has evolved as a measure of the proliferative nature of the glial tumors. This study aims to investigate the MIB-1 index value as an independent prognostic factor in high-grade gliomas and its correlation with outcome and survival. MATERIALS AND METHODS: Mean MIB-1 index was determined in 51 high-grade glioma tissue samples in formalin. Its correlation with outcome by assessing the clinicoradiological parameters and median survival of patients in months were assessed. Survival analysis was studied by using the Kaplan–Meier bivariate analysis and Cox proportional ratio. RESULTS: Preoperative Karnofsky Performance Score, WHO-PS, Neurological Performance Scale, and Mini–Mental Status Examination (MMSE) were statistically significant with respect to outcome and survival, whereas tumor factors such as size and perilesional edema were not. In particular, midline-crossing tumors and deep-seated tumors were significantly associated with high MIB-1 index and by correlation with outcome. There were significantly higher number (P < 0.0001) of patients with Grade IV tumors, with an MIB-1 index value above an arbitrary cutoff of 10% compared to Grade III tumors. In addition, median survival period of patients with low MIB-1 index was longer irrespective of tumor grade. CONCLUSION: Significant correlation between high-grade glioma and MIB-1 index suggests MIB-1 index to be a good prognostic tool, with MIB-1 index and midline-crossing variables being independent prognostic parameters.
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spelling pubmed-64549432019-04-18 Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation Krishnan, Shyam Sundar Muthiah, Shanmugam Rao, Shilpa Salem, Suganthi Srinivasan Madabhushi, Vasudevan Chakravarthy Mahadevan, Anita J Neurosci Rural Pract Original Article INTRODUCTION: Gliomas are the most common brain tumors in adults originating from the glial cells. Glioblastoma multiforme is the most malignant and frequent among all gliomas. In recent years, the antibody Mindbomb Homolog-1 (MIB-1) has evolved as a measure of the proliferative nature of the glial tumors. This study aims to investigate the MIB-1 index value as an independent prognostic factor in high-grade gliomas and its correlation with outcome and survival. MATERIALS AND METHODS: Mean MIB-1 index was determined in 51 high-grade glioma tissue samples in formalin. Its correlation with outcome by assessing the clinicoradiological parameters and median survival of patients in months were assessed. Survival analysis was studied by using the Kaplan–Meier bivariate analysis and Cox proportional ratio. RESULTS: Preoperative Karnofsky Performance Score, WHO-PS, Neurological Performance Scale, and Mini–Mental Status Examination (MMSE) were statistically significant with respect to outcome and survival, whereas tumor factors such as size and perilesional edema were not. In particular, midline-crossing tumors and deep-seated tumors were significantly associated with high MIB-1 index and by correlation with outcome. There were significantly higher number (P < 0.0001) of patients with Grade IV tumors, with an MIB-1 index value above an arbitrary cutoff of 10% compared to Grade III tumors. In addition, median survival period of patients with low MIB-1 index was longer irrespective of tumor grade. CONCLUSION: Significant correlation between high-grade glioma and MIB-1 index suggests MIB-1 index to be a good prognostic tool, with MIB-1 index and midline-crossing variables being independent prognostic parameters. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6454943/ /pubmed/31001003 http://dx.doi.org/10.4103/jnrp.jnrp_374_18 Text en Copyright: © 2019 Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Krishnan, Shyam Sundar
Muthiah, Shanmugam
Rao, Shilpa
Salem, Suganthi Srinivasan
Madabhushi, Vasudevan Chakravarthy
Mahadevan, Anita
Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation
title Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation
title_full Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation
title_fullStr Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation
title_full_unstemmed Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation
title_short Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation
title_sort mindbomb homolog-1 index in the prognosis of high-grade glioma and its clinicopathological correlation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454943/
https://www.ncbi.nlm.nih.gov/pubmed/31001003
http://dx.doi.org/10.4103/jnrp.jnrp_374_18
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