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Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate
Interest in biologically active materials that can be used as cell culture substrates for medicinal applications has increased dramatically over the last decade. The design and development of biomaterials mimicking the natural environment of different cell types, the so-called extracellular matrix (...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455064/ https://www.ncbi.nlm.nih.gov/pubmed/31001512 http://dx.doi.org/10.3389/fchem.2019.00172 |
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author | Hellmund, Katharina S. Koksch, Beate |
author_facet | Hellmund, Katharina S. Koksch, Beate |
author_sort | Hellmund, Katharina S. |
collection | PubMed |
description | Interest in biologically active materials that can be used as cell culture substrates for medicinal applications has increased dramatically over the last decade. The design and development of biomaterials mimicking the natural environment of different cell types, the so-called extracellular matrix (ECM), is the focus of research in this field. The ECM exists as an ensemble of several adhesion proteins with different functionalities that can be presented to the embedded cells. These functionalities regulate numerous cellular processes. Therefore, different approaches and strategies using peptide- and protein-based biopolymers have been investigated to support the proliferation, differentiation, and self-renewal of stem cells, in the context of regenerative medicine. This minireview summarizes recent developments in this area, with a focus on peptide-based biomaterials used as stem cell culture substrates. |
format | Online Article Text |
id | pubmed-6455064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64550642019-04-18 Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate Hellmund, Katharina S. Koksch, Beate Front Chem Chemistry Interest in biologically active materials that can be used as cell culture substrates for medicinal applications has increased dramatically over the last decade. The design and development of biomaterials mimicking the natural environment of different cell types, the so-called extracellular matrix (ECM), is the focus of research in this field. The ECM exists as an ensemble of several adhesion proteins with different functionalities that can be presented to the embedded cells. These functionalities regulate numerous cellular processes. Therefore, different approaches and strategies using peptide- and protein-based biopolymers have been investigated to support the proliferation, differentiation, and self-renewal of stem cells, in the context of regenerative medicine. This minireview summarizes recent developments in this area, with a focus on peptide-based biomaterials used as stem cell culture substrates. Frontiers Media S.A. 2019-03-27 /pmc/articles/PMC6455064/ /pubmed/31001512 http://dx.doi.org/10.3389/fchem.2019.00172 Text en Copyright © 2019 Hellmund and Koksch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Hellmund, Katharina S. Koksch, Beate Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate |
title | Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate |
title_full | Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate |
title_fullStr | Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate |
title_full_unstemmed | Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate |
title_short | Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate |
title_sort | self-assembling peptides as extracellular matrix mimics to influence stem cell's fate |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455064/ https://www.ncbi.nlm.nih.gov/pubmed/31001512 http://dx.doi.org/10.3389/fchem.2019.00172 |
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