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Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography
PURPOSE: To evaluate the validity and reliability of alternative methods for evaluating meibomian gland (MG) dropout without using an infrared light system: red-filtered or isolated red-channel images (RCIs) of the everted eyelid. METHODS: We evaluated MG dropout in the everted upper and lower eyeli...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cornea
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455092/ https://www.ncbi.nlm.nih.gov/pubmed/30789441 http://dx.doi.org/10.1097/ICO.0000000000001892 |
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author | Lee, Sang-Mok Park, Inwon Goo, Yong Ho Choi, Dongchul Shin, Min Chul Kim, Eun Chul Alkwikbi, Hassan Fallaj Kim, Man Soo Hwang, Ho Sik |
author_facet | Lee, Sang-Mok Park, Inwon Goo, Yong Ho Choi, Dongchul Shin, Min Chul Kim, Eun Chul Alkwikbi, Hassan Fallaj Kim, Man Soo Hwang, Ho Sik |
author_sort | Lee, Sang-Mok |
collection | PubMed |
description | PURPOSE: To evaluate the validity and reliability of alternative methods for evaluating meibomian gland (MG) dropout without using an infrared light system: red-filtered or isolated red-channel images (RCIs) of the everted eyelid. METHODS: We evaluated MG dropout in the everted upper and lower eyelids of 125 eyes of 64 patients with good-quality infrared meibography images (IMIs) and color digital photographs with and without a red filter. Red-filtered images (RFIs) were converted to black and white and adjusted for contrast/brightness [adjusted red-filtered images (aRFIs)]. RCIs were computationally isolated from color digital photographs obtained without a red filter. After randomization, the total meiboscore (0–6) was evaluated by 2 independent evaluators (interobserver reliability) masked to the image origin, and again after a 30-day interval (intraobserver reliability). RESULTS: The meiboscores evaluated using the RFI, aRFI, and RCI were strongly positively correlated with those evaluated using the IMI (RFI: ρ = 0.788; aRFI: ρ = 0.735; RCI: ρ = 0.630; all P < 0.001, Spearman correlation analysis). Linear-weighted κ-values (κ(w)) showed substantial agreement between the RFI and IMI (κ(w) = 0.676, 95% CI = 0.594–0.759). The RFI had substantial intraobserver reliability (κ(w) = 0.735, 95% CI = 0.685–0.785) and moderate interobserver reliability (κ(w) = 0.467, 95% CI = 0.371–0.563). Computational adjustment of RFIs did not enhance the validity or reliability, and RCIs had limitations in some cases. CONCLUSIONS: MGs were successfully visualized using a red filter on a slit lamp and showed substantial agreement with visualization using the standard infrared method. Although interobserver reliability was only moderate, this alternative technique may be useful for evaluating MG dropout when an infrared meibography device is not available. |
format | Online Article Text |
id | pubmed-6455092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cornea |
record_format | MEDLINE/PubMed |
spelling | pubmed-64550922019-05-01 Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography Lee, Sang-Mok Park, Inwon Goo, Yong Ho Choi, Dongchul Shin, Min Chul Kim, Eun Chul Alkwikbi, Hassan Fallaj Kim, Man Soo Hwang, Ho Sik Cornea Clinical Science PURPOSE: To evaluate the validity and reliability of alternative methods for evaluating meibomian gland (MG) dropout without using an infrared light system: red-filtered or isolated red-channel images (RCIs) of the everted eyelid. METHODS: We evaluated MG dropout in the everted upper and lower eyelids of 125 eyes of 64 patients with good-quality infrared meibography images (IMIs) and color digital photographs with and without a red filter. Red-filtered images (RFIs) were converted to black and white and adjusted for contrast/brightness [adjusted red-filtered images (aRFIs)]. RCIs were computationally isolated from color digital photographs obtained without a red filter. After randomization, the total meiboscore (0–6) was evaluated by 2 independent evaluators (interobserver reliability) masked to the image origin, and again after a 30-day interval (intraobserver reliability). RESULTS: The meiboscores evaluated using the RFI, aRFI, and RCI were strongly positively correlated with those evaluated using the IMI (RFI: ρ = 0.788; aRFI: ρ = 0.735; RCI: ρ = 0.630; all P < 0.001, Spearman correlation analysis). Linear-weighted κ-values (κ(w)) showed substantial agreement between the RFI and IMI (κ(w) = 0.676, 95% CI = 0.594–0.759). The RFI had substantial intraobserver reliability (κ(w) = 0.735, 95% CI = 0.685–0.785) and moderate interobserver reliability (κ(w) = 0.467, 95% CI = 0.371–0.563). Computational adjustment of RFIs did not enhance the validity or reliability, and RCIs had limitations in some cases. CONCLUSIONS: MGs were successfully visualized using a red filter on a slit lamp and showed substantial agreement with visualization using the standard infrared method. Although interobserver reliability was only moderate, this alternative technique may be useful for evaluating MG dropout when an infrared meibography device is not available. Cornea 2019-05 2019-02-15 /pmc/articles/PMC6455092/ /pubmed/30789441 http://dx.doi.org/10.1097/ICO.0000000000001892 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Clinical Science Lee, Sang-Mok Park, Inwon Goo, Yong Ho Choi, Dongchul Shin, Min Chul Kim, Eun Chul Alkwikbi, Hassan Fallaj Kim, Man Soo Hwang, Ho Sik Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography |
title | Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography |
title_full | Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography |
title_fullStr | Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography |
title_full_unstemmed | Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography |
title_short | Validation of Alternative Methods for Detecting Meibomian Gland Dropout Without an Infrared Light System: Red Filter for Simple and Effective Meibography |
title_sort | validation of alternative methods for detecting meibomian gland dropout without an infrared light system: red filter for simple and effective meibography |
topic | Clinical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455092/ https://www.ncbi.nlm.nih.gov/pubmed/30789441 http://dx.doi.org/10.1097/ICO.0000000000001892 |
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