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The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer

OBJECTIVES: In this study, we aimed to investigate the predictive value of pre-ablative stimulated thyroglobulin (Tg) and Tg/thyroid-stimulating hormone (TSH) to identify lymph node metastasis (LNM) or distant metastases (DM) prior to radioactive iodine (RAI) treatment. METHODS: Patients without met...

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Autores principales: Demir, Fadime, Şimşek, Fikri Selçuk, Ansal Balcı, Tansel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455104/
https://www.ncbi.nlm.nih.gov/pubmed/30942058
http://dx.doi.org/10.4274/mirt.galenos.2018.09825
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author Demir, Fadime
Şimşek, Fikri Selçuk
Ansal Balcı, Tansel
author_facet Demir, Fadime
Şimşek, Fikri Selçuk
Ansal Balcı, Tansel
author_sort Demir, Fadime
collection PubMed
description OBJECTIVES: In this study, we aimed to investigate the predictive value of pre-ablative stimulated thyroglobulin (Tg) and Tg/thyroid-stimulating hormone (TSH) to identify lymph node metastasis (LNM) or distant metastases (DM) prior to radioactive iodine (RAI) treatment. METHODS: Patients without metastasis were included in group 1 (n=100), those with LNM were included in group 2 (n=83), and those with DM constituted group 3 (n=23). Tg and TSH values were measured approximately 4 hours prior to RAI ablation therapy. RESULTS: There was a significant difference between group 3 and other groups (group 1 and group 2) in terms of Tg (p<0.001) and Tg/ TSH (p<0.001). For Tg level and Tg/TSH ratio, the areas under ROC were 0.990 [95% confidence interval (CI): 0.979-1] and 0.991 (95% CI: 0.981-1), respectively. The cut-off points for Tg and Tg/TSH were 102 ng/mL and 1.06, respectively. CONCLUSION: Our results suggest that Tg and Tg/TSH values can be used to predict DM. On the other hand, our study indicates that patients should be carefully evaluated for LNM even when Tg levels are low.
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spelling pubmed-64551042019-04-18 The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer Demir, Fadime Şimşek, Fikri Selçuk Ansal Balcı, Tansel Mol Imaging Radionucl Ther Original Article OBJECTIVES: In this study, we aimed to investigate the predictive value of pre-ablative stimulated thyroglobulin (Tg) and Tg/thyroid-stimulating hormone (TSH) to identify lymph node metastasis (LNM) or distant metastases (DM) prior to radioactive iodine (RAI) treatment. METHODS: Patients without metastasis were included in group 1 (n=100), those with LNM were included in group 2 (n=83), and those with DM constituted group 3 (n=23). Tg and TSH values were measured approximately 4 hours prior to RAI ablation therapy. RESULTS: There was a significant difference between group 3 and other groups (group 1 and group 2) in terms of Tg (p<0.001) and Tg/ TSH (p<0.001). For Tg level and Tg/TSH ratio, the areas under ROC were 0.990 [95% confidence interval (CI): 0.979-1] and 0.991 (95% CI: 0.981-1), respectively. The cut-off points for Tg and Tg/TSH were 102 ng/mL and 1.06, respectively. CONCLUSION: Our results suggest that Tg and Tg/TSH values can be used to predict DM. On the other hand, our study indicates that patients should be carefully evaluated for LNM even when Tg levels are low. Galenos Publishing 2019-02 2019-03-19 /pmc/articles/PMC6455104/ /pubmed/30942058 http://dx.doi.org/10.4274/mirt.galenos.2018.09825 Text en ©Copyright 2019 by Turkish Society of Nuclear Medicine | Molecular Imaging and Radionuclide Therapy published by Galenos Yayınevi. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Demir, Fadime
Şimşek, Fikri Selçuk
Ansal Balcı, Tansel
The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer
title The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer
title_full The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer
title_fullStr The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer
title_full_unstemmed The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer
title_short The Role of Pre-ablative Stimulated Thyroglobulin and Thyroglobulin/ Thyroid-Stimulating Hormone Ratio for Predicting Metastasis in Thyroid Cancer
title_sort role of pre-ablative stimulated thyroglobulin and thyroglobulin/ thyroid-stimulating hormone ratio for predicting metastasis in thyroid cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455104/
https://www.ncbi.nlm.nih.gov/pubmed/30942058
http://dx.doi.org/10.4274/mirt.galenos.2018.09825
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