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Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature

RATIONALE: Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according t...

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Autores principales: Yang, Kun, Jiang, Huifeng, Li, Qiuyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455993/
https://www.ncbi.nlm.nih.gov/pubmed/30946350
http://dx.doi.org/10.1097/MD.0000000000015053
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author Yang, Kun
Jiang, Huifeng
Li, Qiuyao
author_facet Yang, Kun
Jiang, Huifeng
Li, Qiuyao
author_sort Yang, Kun
collection PubMed
description RATIONALE: Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagnostic criteria. Despite that HAC exhibits a poor prognosis and ineffective treatment options, early diagnosis and aggressive treatment can result in long-term survival. PATIENT CONCERNS: We report a 70-year-old Chinese male patient with alcoholic intake over 30 years and smoking history of 60 cigarettes per day for 40 years. He sought medical consultation for productive cough and hemoptysis sputum. DIAGNOSES AND INTERVENTIONS: Chest CT scan revealed a mass (6.4 × 5.5 cm) in the left lower lobe of the lung. The patient underwent curative surgical resection, and subsequently diagnosed as HAL. OUTCOMES: Eighteen months after primary diagnosis, the patient died of multiple organ failure caused by distant metastases. LESSONS: Familiarizing with the clinical features and modified diagnostic criteria of this rare tumor may increase awareness of the disease among clinicians and pathologists, thereby avoiding misdiagnosis and mistreatment.
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spelling pubmed-64559932019-05-29 Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature Yang, Kun Jiang, Huifeng Li, Qiuyao Medicine (Baltimore) Research Article RATIONALE: Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagnostic criteria. Despite that HAC exhibits a poor prognosis and ineffective treatment options, early diagnosis and aggressive treatment can result in long-term survival. PATIENT CONCERNS: We report a 70-year-old Chinese male patient with alcoholic intake over 30 years and smoking history of 60 cigarettes per day for 40 years. He sought medical consultation for productive cough and hemoptysis sputum. DIAGNOSES AND INTERVENTIONS: Chest CT scan revealed a mass (6.4 × 5.5 cm) in the left lower lobe of the lung. The patient underwent curative surgical resection, and subsequently diagnosed as HAL. OUTCOMES: Eighteen months after primary diagnosis, the patient died of multiple organ failure caused by distant metastases. LESSONS: Familiarizing with the clinical features and modified diagnostic criteria of this rare tumor may increase awareness of the disease among clinicians and pathologists, thereby avoiding misdiagnosis and mistreatment. Wolters Kluwer Health 2019-04-05 /pmc/articles/PMC6455993/ /pubmed/30946350 http://dx.doi.org/10.1097/MD.0000000000015053 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Yang, Kun
Jiang, Huifeng
Li, Qiuyao
Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature
title Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature
title_full Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature
title_fullStr Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature
title_full_unstemmed Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature
title_short Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature
title_sort primary pulmonary hepatoid adenocarcinoma: a case report and review of the literature
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455993/
https://www.ncbi.nlm.nih.gov/pubmed/30946350
http://dx.doi.org/10.1097/MD.0000000000015053
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