Cargando…

Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis

BACKGROUND: Multiple sclerosis (MS) is one of the most common neurological disorders and is one of the main causes of disability. The prevalence and incidence of MS in Iran is reported to range from 5.3 to 89/ 100,000and 7 to 148.1/ 100,000, respectively. There are no systematic and meta-analysis st...

Descripción completa

Detalles Bibliográficos
Autores principales: Azami, Milad, YektaKooshali, Mohammad Hossein, Shohani, Masoumeh, Khorshidi, Ali, Mahmudi, Leily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456231/
https://www.ncbi.nlm.nih.gov/pubmed/30964886
http://dx.doi.org/10.1371/journal.pone.0214738
_version_ 1783409736398405632
author Azami, Milad
YektaKooshali, Mohammad Hossein
Shohani, Masoumeh
Khorshidi, Ali
Mahmudi, Leily
author_facet Azami, Milad
YektaKooshali, Mohammad Hossein
Shohani, Masoumeh
Khorshidi, Ali
Mahmudi, Leily
author_sort Azami, Milad
collection PubMed
description BACKGROUND: Multiple sclerosis (MS) is one of the most common neurological disorders and is one of the main causes of disability. The prevalence and incidence of MS in Iran is reported to range from 5.3 to 89/ 100,000and 7 to 148.1/ 100,000, respectively. There are no systematic and meta-analysis studies on MS in Iran. Therefore, this study was conducted to investigate the prevalence and incidence of MS in Iran using meta-analysis. METHOD: A systematic review of the present study focused on MS epidemiology in Iran based on PRISMA guidelines for systematic review and meta-analysis. We searched eight international databases including Scopus, PubMed, Science Direct, Cochrane Library, Web of Science, EMBASE, PsycINFO, Google Scholar search engine and six Persian databases for peer-reviewed studies published without time limit until May 2018. Data were analyzed using Comprehensive meta-analysis ver. 2 software. The review protocol has been registered in PROSPERO with ID: CRD42018114491. RESULTS: According to searching on different databases, 39 (15%) articles finalized. The prevalence of MS in Iran was estimated 29.3/ 100,000 (95%CI: 25.6–33.5) based on random effects model. The prevalence of MS in men and women was estimated to be 16.5/ 100,000 (95%CI: 13.7–23.4) and 44.8/ 100,000 (95%CI: 36.3–61.6), respectively. The incidence of MS in Iran was estimated to be 3.4/ 100,000 (95%CI: 1.8–6.2) based on random effects model. The incidence of MS in men was estimated to be 16.5/ 100,000 (95%CI: 13.7–23.4) and the incidence of MS in women was 44.8/ 100,000 (95%CI: 36.3–61.6). The meta-regression model for prevalence and incidence of MS was significantly higher in terms of year of study (p<0.001). CONCLUSIONS: The results of this study can provide a general picture of MS epidemiology in Iran. The current meta-analysis showed that the prevalence and incidence of MS in Iran is high and is rising over time.
format Online
Article
Text
id pubmed-6456231
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-64562312019-05-03 Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis Azami, Milad YektaKooshali, Mohammad Hossein Shohani, Masoumeh Khorshidi, Ali Mahmudi, Leily PLoS One Research Article BACKGROUND: Multiple sclerosis (MS) is one of the most common neurological disorders and is one of the main causes of disability. The prevalence and incidence of MS in Iran is reported to range from 5.3 to 89/ 100,000and 7 to 148.1/ 100,000, respectively. There are no systematic and meta-analysis studies on MS in Iran. Therefore, this study was conducted to investigate the prevalence and incidence of MS in Iran using meta-analysis. METHOD: A systematic review of the present study focused on MS epidemiology in Iran based on PRISMA guidelines for systematic review and meta-analysis. We searched eight international databases including Scopus, PubMed, Science Direct, Cochrane Library, Web of Science, EMBASE, PsycINFO, Google Scholar search engine and six Persian databases for peer-reviewed studies published without time limit until May 2018. Data were analyzed using Comprehensive meta-analysis ver. 2 software. The review protocol has been registered in PROSPERO with ID: CRD42018114491. RESULTS: According to searching on different databases, 39 (15%) articles finalized. The prevalence of MS in Iran was estimated 29.3/ 100,000 (95%CI: 25.6–33.5) based on random effects model. The prevalence of MS in men and women was estimated to be 16.5/ 100,000 (95%CI: 13.7–23.4) and 44.8/ 100,000 (95%CI: 36.3–61.6), respectively. The incidence of MS in Iran was estimated to be 3.4/ 100,000 (95%CI: 1.8–6.2) based on random effects model. The incidence of MS in men was estimated to be 16.5/ 100,000 (95%CI: 13.7–23.4) and the incidence of MS in women was 44.8/ 100,000 (95%CI: 36.3–61.6). The meta-regression model for prevalence and incidence of MS was significantly higher in terms of year of study (p<0.001). CONCLUSIONS: The results of this study can provide a general picture of MS epidemiology in Iran. The current meta-analysis showed that the prevalence and incidence of MS in Iran is high and is rising over time. Public Library of Science 2019-04-09 /pmc/articles/PMC6456231/ /pubmed/30964886 http://dx.doi.org/10.1371/journal.pone.0214738 Text en © 2019 Azami et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Azami, Milad
YektaKooshali, Mohammad Hossein
Shohani, Masoumeh
Khorshidi, Ali
Mahmudi, Leily
Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis
title Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis
title_full Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis
title_fullStr Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis
title_full_unstemmed Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis
title_short Epidemiology of multiple sclerosis in Iran: A systematic review and meta-analysis
title_sort epidemiology of multiple sclerosis in iran: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456231/
https://www.ncbi.nlm.nih.gov/pubmed/30964886
http://dx.doi.org/10.1371/journal.pone.0214738
work_keys_str_mv AT azamimilad epidemiologyofmultiplesclerosisiniranasystematicreviewandmetaanalysis
AT yektakooshalimohammadhossein epidemiologyofmultiplesclerosisiniranasystematicreviewandmetaanalysis
AT shohanimasoumeh epidemiologyofmultiplesclerosisiniranasystematicreviewandmetaanalysis
AT khorshidiali epidemiologyofmultiplesclerosisiniranasystematicreviewandmetaanalysis
AT mahmudileily epidemiologyofmultiplesclerosisiniranasystematicreviewandmetaanalysis