Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that advanced chordomas (n = 11) may be characterized by genomic patterns indicative of defective homologous recombination (HR) DNA repair and alter...

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Detalles Bibliográficos
Autores principales: Gröschel, Stefan, Hübschmann, Daniel, Raimondi, Francesco, Horak, Peter, Warsow, Gregor, Fröhlich, Martina, Klink, Barbara, Gieldon, Laura, Hutter, Barbara, Kleinheinz, Kortine, Bonekamp, David, Marschal, Oliver, Chudasama, Priya, Mika, Jagoda, Groth, Marie, Uhrig, Sebastian, Krämer, Stephen, Heining, Christoph, Heilig, Christoph E., Richter, Daniela, Reisinger, Eva, Pfütze, Katrin, Eils, Roland, Wolf, Stephan, von Kalle, Christof, Brandts, Christian, Scholl, Claudia, Weichert, Wilko, Richter, Stephan, Bauer, Sebastian, Penzel, Roland, Schröck, Evelin, Stenzinger, Albrecht, Schlenk, Richard F., Brors, Benedikt, Russell, Robert B., Glimm, Hanno, Schlesner, Matthias, Fröhling, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456501/
https://www.ncbi.nlm.nih.gov/pubmed/30967556
http://dx.doi.org/10.1038/s41467-019-09633-9

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