The Chemogenetic Receptor Ligand Clozapine N-Oxide Induces in vivo Neuroreceptor Occupancy and Reduces Striatal Glutamate Levels

Chemogenetic studies with the ligand clozapine N-oxide (CNO) are predicated upon the assumption that CNO is devoid of actions at natural neuroreceptors. However, recent evidence shows that CNO may be converted back to clozapine (CLZ) in vivo, which could yield plasma concentrations that may be suffi...

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Detalles Bibliográficos
Autores principales: Bærentzen, Simone, Casado-Sainz, Agata, Lange, Denise, Shalgunov, Vladimir, Tejada, Isabel Martinez, Xiong, Mengfei, L’Estrade, Elina T., Edgar, Fraser G., Lee, Hedok, Herth, Matthias M., Palner, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456655/
https://www.ncbi.nlm.nih.gov/pubmed/31001069
http://dx.doi.org/10.3389/fnins.2019.00187

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