Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer caused by the deregulation of key T-cell developmental pathways, including Notch signaling. Aberrant Notch signaling in T-ALL occurs by NOTCH1 gain-of-function mutations and by NOTCH3 overexpression. Although NOTCH3 is assumed...

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Detalles Bibliográficos
Autores principales: Tottone, Luca, Zhdanovskaya, Nadezda, Carmona Pestaña, Álvaro, Zampieri, Michele, Simeoni, Fabrizio, Lazzari, Sara, Ruocco, Valeria, Pelullo, Maria, Caiafa, Paola, Felli, Maria Pia, Checquolo, Saula, Bellavia, Diana, Talora, Claudio, Screpanti, Isabella, Palermo, Rocco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456714/
https://www.ncbi.nlm.nih.gov/pubmed/31001470
http://dx.doi.org/10.3389/fonc.2019.00198

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