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StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins
Robust approaches for chemogenetic control of protein function would enable many biological applications. We describe stabilizable polypeptide linkages (StaPLs) based on hepatitis C virus protease. StaPLs undergo autoproteolysis to cleave proteins by default, while protease inhibitors prevent cleava...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456726/ https://www.ncbi.nlm.nih.gov/pubmed/29967496 http://dx.doi.org/10.1038/s41592-018-0041-z |