Cargando…
Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
OBJECTIVE: Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456778/ https://www.ncbi.nlm.nih.gov/pubmed/30884164 http://dx.doi.org/10.1002/brb3.1261 |
_version_ | 1783409808188112896 |
---|---|
author | Xu, Wen‐Bin Hu, Qian‐Hua Wu, Chan‐Ni Fan, Zhi‐Kun Song, Zhang‐Fa |
author_facet | Xu, Wen‐Bin Hu, Qian‐Hua Wu, Chan‐Ni Fan, Zhi‐Kun Song, Zhang‐Fa |
author_sort | Xu, Wen‐Bin |
collection | PubMed |
description | OBJECTIVE: Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute pancreatitis (AP). MATERIALS AND METHODS: In this prospective, observational study, serum sFGL2 concentrations were quantified in 184 healthy controls and in 184 AP patients. Disease severity was assessed by Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, and sequential organ failure assessment score. Delirium was recorded during hospital stay. Predictors of delirium were identified using multivariate analysis. RESULTS: Serum sFGL2 concentrations were substantially higher in AP patients than in controls. Serum sFGL2 concentrations were intimately correlated with the preceding severity parameters. Serum sFGL2 and the aforementioned severity parameters were independent predictors for delirium. Under receiver operating characteristic curve, the discriminatory ability of serum sFGL2 was equivalent to those of the above‐mentioned severity parameters. Moreover, serum sFGL2 dramatically improved the predictive value of the aforementioned severity parameters. CONCLUSIONS: Elevation of serum sFGL2 concentrations is strongly associated with the AP severity and has the potential to distinguish delirium after AP. |
format | Online Article Text |
id | pubmed-6456778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64567782019-04-19 Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis Xu, Wen‐Bin Hu, Qian‐Hua Wu, Chan‐Ni Fan, Zhi‐Kun Song, Zhang‐Fa Brain Behav Original Research OBJECTIVE: Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute pancreatitis (AP). MATERIALS AND METHODS: In this prospective, observational study, serum sFGL2 concentrations were quantified in 184 healthy controls and in 184 AP patients. Disease severity was assessed by Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, and sequential organ failure assessment score. Delirium was recorded during hospital stay. Predictors of delirium were identified using multivariate analysis. RESULTS: Serum sFGL2 concentrations were substantially higher in AP patients than in controls. Serum sFGL2 concentrations were intimately correlated with the preceding severity parameters. Serum sFGL2 and the aforementioned severity parameters were independent predictors for delirium. Under receiver operating characteristic curve, the discriminatory ability of serum sFGL2 was equivalent to those of the above‐mentioned severity parameters. Moreover, serum sFGL2 dramatically improved the predictive value of the aforementioned severity parameters. CONCLUSIONS: Elevation of serum sFGL2 concentrations is strongly associated with the AP severity and has the potential to distinguish delirium after AP. John Wiley and Sons Inc. 2019-03-18 /pmc/articles/PMC6456778/ /pubmed/30884164 http://dx.doi.org/10.1002/brb3.1261 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Xu, Wen‐Bin Hu, Qian‐Hua Wu, Chan‐Ni Fan, Zhi‐Kun Song, Zhang‐Fa Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
title | Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
title_full | Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
title_fullStr | Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
title_full_unstemmed | Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
title_short | Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
title_sort | serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456778/ https://www.ncbi.nlm.nih.gov/pubmed/30884164 http://dx.doi.org/10.1002/brb3.1261 |
work_keys_str_mv | AT xuwenbin serumsolublefibrinogenlikeprotein2concentrationpredictsdeliriumafteracutepancreatitis AT huqianhua serumsolublefibrinogenlikeprotein2concentrationpredictsdeliriumafteracutepancreatitis AT wuchanni serumsolublefibrinogenlikeprotein2concentrationpredictsdeliriumafteracutepancreatitis AT fanzhikun serumsolublefibrinogenlikeprotein2concentrationpredictsdeliriumafteracutepancreatitis AT songzhangfa serumsolublefibrinogenlikeprotein2concentrationpredictsdeliriumafteracutepancreatitis |