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Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis

OBJECTIVE: Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute...

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Autores principales: Xu, Wen‐Bin, Hu, Qian‐Hua, Wu, Chan‐Ni, Fan, Zhi‐Kun, Song, Zhang‐Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456778/
https://www.ncbi.nlm.nih.gov/pubmed/30884164
http://dx.doi.org/10.1002/brb3.1261
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author Xu, Wen‐Bin
Hu, Qian‐Hua
Wu, Chan‐Ni
Fan, Zhi‐Kun
Song, Zhang‐Fa
author_facet Xu, Wen‐Bin
Hu, Qian‐Hua
Wu, Chan‐Ni
Fan, Zhi‐Kun
Song, Zhang‐Fa
author_sort Xu, Wen‐Bin
collection PubMed
description OBJECTIVE: Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute pancreatitis (AP). MATERIALS AND METHODS: In this prospective, observational study, serum sFGL2 concentrations were quantified in 184 healthy controls and in 184 AP patients. Disease severity was assessed by Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, and sequential organ failure assessment score. Delirium was recorded during hospital stay. Predictors of delirium were identified using multivariate analysis. RESULTS: Serum sFGL2 concentrations were substantially higher in AP patients than in controls. Serum sFGL2 concentrations were intimately correlated with the preceding severity parameters. Serum sFGL2 and the aforementioned severity parameters were independent predictors for delirium. Under receiver operating characteristic curve, the discriminatory ability of serum sFGL2 was equivalent to those of the above‐mentioned severity parameters. Moreover, serum sFGL2 dramatically improved the predictive value of the aforementioned severity parameters. CONCLUSIONS: Elevation of serum sFGL2 concentrations is strongly associated with the AP severity and has the potential to distinguish delirium after AP.
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spelling pubmed-64567782019-04-19 Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis Xu, Wen‐Bin Hu, Qian‐Hua Wu, Chan‐Ni Fan, Zhi‐Kun Song, Zhang‐Fa Brain Behav Original Research OBJECTIVE: Inflammation can cause delirium. Soluble fibrinogen‐like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute pancreatitis (AP). MATERIALS AND METHODS: In this prospective, observational study, serum sFGL2 concentrations were quantified in 184 healthy controls and in 184 AP patients. Disease severity was assessed by Acute Physiology and Chronic Health Care Evaluation II score, Ranson score, multiple organ dysfunction score, and sequential organ failure assessment score. Delirium was recorded during hospital stay. Predictors of delirium were identified using multivariate analysis. RESULTS: Serum sFGL2 concentrations were substantially higher in AP patients than in controls. Serum sFGL2 concentrations were intimately correlated with the preceding severity parameters. Serum sFGL2 and the aforementioned severity parameters were independent predictors for delirium. Under receiver operating characteristic curve, the discriminatory ability of serum sFGL2 was equivalent to those of the above‐mentioned severity parameters. Moreover, serum sFGL2 dramatically improved the predictive value of the aforementioned severity parameters. CONCLUSIONS: Elevation of serum sFGL2 concentrations is strongly associated with the AP severity and has the potential to distinguish delirium after AP. John Wiley and Sons Inc. 2019-03-18 /pmc/articles/PMC6456778/ /pubmed/30884164 http://dx.doi.org/10.1002/brb3.1261 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Xu, Wen‐Bin
Hu, Qian‐Hua
Wu, Chan‐Ni
Fan, Zhi‐Kun
Song, Zhang‐Fa
Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
title Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
title_full Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
title_fullStr Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
title_full_unstemmed Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
title_short Serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
title_sort serum soluble fibrinogen‐like protein 2 concentration predicts delirium after acute pancreatitis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456778/
https://www.ncbi.nlm.nih.gov/pubmed/30884164
http://dx.doi.org/10.1002/brb3.1261
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