Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis

Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across the blood-brain barrier, as well as intrinsic and acquired drug resistance. Augm...

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Detalles Bibliográficos
Autores principales: Sundstrøm, Terje, Prestegarden, Lars, Azuaje, Francisco, Aasen, Synnøve Nymark, Røsland, Gro Vatne, Varughese, Jobin K., Bahador, Marzieh, Bernatz, Simon, Braun, Yannick, Harter, Patrick N., Skaftnesmo, Kai Ove, Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah, Tepper, Clifford G., Petersen, Kjell, Ferrara, Katherine W., Tronstad, Karl Johan, Lund-Johansen, Morten, Beschorner, Rudi, Bjerkvig, Rolf, Thorsen, Frits
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456988/
https://www.ncbi.nlm.nih.gov/pubmed/30971321
http://dx.doi.org/10.1186/s40478-019-0712-8

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