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Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

BACKGROUND: Central sensitization is an important mechanism of chronic migraine (CM) and is related to the inflammatory response of microglia. The NOD-like receptor protein 3 (NLRP3) inflammasome may regulate the inflammatory process of microglia in several neurological diseases, but its role in CM...

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Detalles Bibliográficos
Autores principales: He, Wei, Long, Ting, Pan, Qi, Zhang, Shanshan, Zhang, Yixin, Zhang, Dunke, Qin, Guangcheng, Chen, Lixue, Zhou, Jiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456991/
https://www.ncbi.nlm.nih.gov/pubmed/30971286
http://dx.doi.org/10.1186/s12974-019-1459-7