African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker

BACKGROUND: Today, the development of new and well-tolerated anti-malarial drugs is strongly justified by the emergence of Plasmodium falciparum resistance. In 2014–2015, a phase 2b clinical study was conducted to evaluate the efficacy of a single oral dose of Artefenomel (OZ439)–piperaquine (PPQ) i...

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Detalles Bibliográficos
Autores principales: Leroy, Didier, Macintyre, Fiona, Adoke, Yeka, Ouoba, Serge, Barry, Aissata, Mombo-Ngoma, Ghyslain, Ndong Ngomo, Jacques Mari, Varo, Rosauro, Dossou, Yannelle, Tshefu, Antoinette Kitoto, Duong, Tran Thanh, Phuc, Bui Quang, Laurijssens, Bart, Klopper, Roland, Khim, Nimol, Legrand, Eric, Ménard, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457011/
https://www.ncbi.nlm.nih.gov/pubmed/30967148
http://dx.doi.org/10.1186/s12936-019-2756-4

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