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Gut Microbiota and Overweight in 3-year Old Children

BACKGROUND: The gut microbiota has been associated with overweight and obesity in adults, but the evidence in children is limited. Our aim was to study whether composition of the gut microbiota at the age of 3 years is associated with overweight/obesity in children cross-sectionally. METHODS: Childr...

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Autores principales: Karvonen, Anne M., Sordillo, Joanne E., Gold, Diane R., Bacharier, Leonard B., O’Connor, George T., Zeiger, Robert S., Beigelman, Avraham, Weiss, Scott T., Litonjua, Augusto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457121/
https://www.ncbi.nlm.nih.gov/pubmed/30568265
http://dx.doi.org/10.1038/s41366-018-0290-z
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author Karvonen, Anne M.
Sordillo, Joanne E.
Gold, Diane R.
Bacharier, Leonard B.
O’Connor, George T.
Zeiger, Robert S.
Beigelman, Avraham
Weiss, Scott T.
Litonjua, Augusto A.
author_facet Karvonen, Anne M.
Sordillo, Joanne E.
Gold, Diane R.
Bacharier, Leonard B.
O’Connor, George T.
Zeiger, Robert S.
Beigelman, Avraham
Weiss, Scott T.
Litonjua, Augusto A.
author_sort Karvonen, Anne M.
collection PubMed
description BACKGROUND: The gut microbiota has been associated with overweight and obesity in adults, but the evidence in children is limited. Our aim was to study whether composition of the gut microbiota at the age of 3 years is associated with overweight/obesity in children cross-sectionally. METHODS: Children, who participated in a clinical trial of prenatal vitamin-D supplementation (VDAART), underwent standardized height and weight measurements, and collection of stool samples at three years of age. 16S rRNA sequencing (V4 region) of the stool samples were performed with Illumina MiSeq. Associations between microbiota and overweight/obesity (body mass index z-scores > 85(th) percentile) was analyzed using logistic regression. RESULTS: Out of 502 children, 146 (29%) were categorized as overweight/obese. Maternal pre-pregnancy BMI, birth weight and length, formula feeding during the first year, high frequency of fast food consumption, and time watching TV or computer screen at 3 years were the risk factors for overweight/obesity. Of the top 20 most abundant genera, high relative abundance of Parabacteroidetes(Bacteroidetes;Bacteroidales) (aOR(95%CI): 0.69(0.53, 0.90, p=0.007) per interquartile increase) and unassigned genus within Peptostreptococcae family were inversely associated with overweight/obesity, whereas high relative abundance of Dorea(Firmicutes;Clostridiales) (1.23 (1.05,1.43, p=0.009)) was positively associated. Associations were independent of each other. No associations were found between diversity indices and overweight/obesity. CONCLUSIONS: Our data suggest that some of the differences in gut composition of bacteria between obese and non-obese adults can already be observed in 3-year old children. Longitudinal studies will be needed to determine long-term effects.
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spelling pubmed-64571212019-06-19 Gut Microbiota and Overweight in 3-year Old Children Karvonen, Anne M. Sordillo, Joanne E. Gold, Diane R. Bacharier, Leonard B. O’Connor, George T. Zeiger, Robert S. Beigelman, Avraham Weiss, Scott T. Litonjua, Augusto A. Int J Obes (Lond) Article BACKGROUND: The gut microbiota has been associated with overweight and obesity in adults, but the evidence in children is limited. Our aim was to study whether composition of the gut microbiota at the age of 3 years is associated with overweight/obesity in children cross-sectionally. METHODS: Children, who participated in a clinical trial of prenatal vitamin-D supplementation (VDAART), underwent standardized height and weight measurements, and collection of stool samples at three years of age. 16S rRNA sequencing (V4 region) of the stool samples were performed with Illumina MiSeq. Associations between microbiota and overweight/obesity (body mass index z-scores > 85(th) percentile) was analyzed using logistic regression. RESULTS: Out of 502 children, 146 (29%) were categorized as overweight/obese. Maternal pre-pregnancy BMI, birth weight and length, formula feeding during the first year, high frequency of fast food consumption, and time watching TV or computer screen at 3 years were the risk factors for overweight/obesity. Of the top 20 most abundant genera, high relative abundance of Parabacteroidetes(Bacteroidetes;Bacteroidales) (aOR(95%CI): 0.69(0.53, 0.90, p=0.007) per interquartile increase) and unassigned genus within Peptostreptococcae family were inversely associated with overweight/obesity, whereas high relative abundance of Dorea(Firmicutes;Clostridiales) (1.23 (1.05,1.43, p=0.009)) was positively associated. Associations were independent of each other. No associations were found between diversity indices and overweight/obesity. CONCLUSIONS: Our data suggest that some of the differences in gut composition of bacteria between obese and non-obese adults can already be observed in 3-year old children. Longitudinal studies will be needed to determine long-term effects. 2018-12-19 2019-04 /pmc/articles/PMC6457121/ /pubmed/30568265 http://dx.doi.org/10.1038/s41366-018-0290-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Karvonen, Anne M.
Sordillo, Joanne E.
Gold, Diane R.
Bacharier, Leonard B.
O’Connor, George T.
Zeiger, Robert S.
Beigelman, Avraham
Weiss, Scott T.
Litonjua, Augusto A.
Gut Microbiota and Overweight in 3-year Old Children
title Gut Microbiota and Overweight in 3-year Old Children
title_full Gut Microbiota and Overweight in 3-year Old Children
title_fullStr Gut Microbiota and Overweight in 3-year Old Children
title_full_unstemmed Gut Microbiota and Overweight in 3-year Old Children
title_short Gut Microbiota and Overweight in 3-year Old Children
title_sort gut microbiota and overweight in 3-year old children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457121/
https://www.ncbi.nlm.nih.gov/pubmed/30568265
http://dx.doi.org/10.1038/s41366-018-0290-z
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