Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA

We report proof of principle biomimetic switching of transcription in vitro through non-natural chemical reactions in the major groove of DNA templates. Photocaged DNA templates containing nitrobenzyl-protected 5-hydroxymethyluracil or – cytosine permitted no transcription with E. coli RNA polymeras...

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Detalles Bibliográficos
Autores principales: Vaníková, Zuzana, Janoušková, Martina, Kambová, Milada, Krásný, Libor, Hocek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457204/
https://www.ncbi.nlm.nih.gov/pubmed/31015933
http://dx.doi.org/10.1039/c9sc00205g

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