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Complement in Metastasis: A Comp in the Camp

The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one...

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Autores principales: Ajona, Daniel, Ortiz-Espinosa, Sergio, Pio, Ruben, Lecanda, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457318/
https://www.ncbi.nlm.nih.gov/pubmed/31001273
http://dx.doi.org/10.3389/fimmu.2019.00669
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author Ajona, Daniel
Ortiz-Espinosa, Sergio
Pio, Ruben
Lecanda, Fernando
author_facet Ajona, Daniel
Ortiz-Espinosa, Sergio
Pio, Ruben
Lecanda, Fernando
author_sort Ajona, Daniel
collection PubMed
description The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a tour d'horizon on recent advances in this area and their prospective potential for cancer treatment.
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spelling pubmed-64573182019-04-18 Complement in Metastasis: A Comp in the Camp Ajona, Daniel Ortiz-Espinosa, Sergio Pio, Ruben Lecanda, Fernando Front Immunol Immunology The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a tour d'horizon on recent advances in this area and their prospective potential for cancer treatment. Frontiers Media S.A. 2019-04-03 /pmc/articles/PMC6457318/ /pubmed/31001273 http://dx.doi.org/10.3389/fimmu.2019.00669 Text en Copyright © 2019 Ajona, Ortiz-Espinosa, Pio and Lecanda. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ajona, Daniel
Ortiz-Espinosa, Sergio
Pio, Ruben
Lecanda, Fernando
Complement in Metastasis: A Comp in the Camp
title Complement in Metastasis: A Comp in the Camp
title_full Complement in Metastasis: A Comp in the Camp
title_fullStr Complement in Metastasis: A Comp in the Camp
title_full_unstemmed Complement in Metastasis: A Comp in the Camp
title_short Complement in Metastasis: A Comp in the Camp
title_sort complement in metastasis: a comp in the camp
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457318/
https://www.ncbi.nlm.nih.gov/pubmed/31001273
http://dx.doi.org/10.3389/fimmu.2019.00669
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