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Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition
Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies. Here we demonstrate that treating the CEP with matrix metalloproteinase-8 (MMP-8) reduces the matrix constituents that impede solute...
Autores principales: | Dolor, Aaron, Sampson, Sara L., Lazar, Ann A., Lotz, Jeffrey C., Szoka, Francis C., Fields, Aaron J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457523/ https://www.ncbi.nlm.nih.gov/pubmed/30970007 http://dx.doi.org/10.1371/journal.pone.0215218 |
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