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Estimation of the breadth of CD4bs targeting HIV antibodies by molecular modeling and machine learning

HIV is a highly mutable virus for which all attempts to develop a vaccine have been unsuccessful. Nevertheless, few long-infected patients develop antibodies, called broadly neutralizing antibodies (bnAbs), that have a high breadth and can neutralize multiple variants of the virus. This suggests tha...

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Detalles Bibliográficos
Autores principales: Conti, Simone, Karplus, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457539/
https://www.ncbi.nlm.nih.gov/pubmed/30970017
http://dx.doi.org/10.1371/journal.pcbi.1006954