Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer

Glycogen synthase kinase-3 (GSK3) is over-expressed and hyperactivated in non-small cell lung carcinoma (NSCLC) and plays a role in ensuring the correct alignment of chromosomes on the metaphase plate during mitosis through regulation of microtubule stability. This makes the enzyme an attractive tar...

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Detalles Bibliográficos
Autores principales: O’Flaherty, Linda, Shnyder, Steven D., Cooper, Patricia A., Cross, Stephen J., Wakefield, James G., Pardo, Olivier E., Seckl, Michael J., Tavaré, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457575/
https://www.ncbi.nlm.nih.gov/pubmed/30969984
http://dx.doi.org/10.1371/journal.pone.0214610

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