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TGF-β Signalling is Suppressed under Pro-Hypertrophic Conditions in MSC Chondrogenesis Due to TGF-β Receptor Downregulation

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) become hypertrophic in long term despite chondrogenic differentiation following the pathway of growth plate chondrocytes. This terminal differentiation leads to phenotypically unstable cartilage and was mirrored in vitro by addition of hypertr...

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Detalles Bibliográficos
Autores principales:	Pfeifer, Christian G., Karl, Alexandra, Kerschbaum, Maximilian, Berner, Arne, Lang, Siegmund, Schupfner, Rupert, Koch, Matthias, Angele, Peter, Nerlich, Michael, Mueller, Michael B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Stem Cell Research 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457698/ https://www.ncbi.nlm.nih.gov/pubmed/30836731 http://dx.doi.org/10.15283/ijsc18088

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