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Generalization of learned responses in the mormyrid electrosensory lobe

Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corol...

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Detalles Bibliográficos
Autores principales: Dempsey, Conor, Abbott, LF, Sawtell, Nathaniel B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457893/
https://www.ncbi.nlm.nih.gov/pubmed/30860480
http://dx.doi.org/10.7554/eLife.44032
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author Dempsey, Conor
Abbott, LF
Sawtell, Nathaniel B
author_facet Dempsey, Conor
Abbott, LF
Sawtell, Nathaniel B
author_sort Dempsey, Conor
collection PubMed
description Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corollary discharge signals cancel responses to the uninformative input evoked by the fish’s own electric pulses. However, for this cancellation to be useful under natural circumstances, it must generalize accurately across behavioral regimes, specifically different electric pulse rates. We show that such generalization indeed occurs in ELL neurons, and develop a circuit-level model explaining how this may be achieved. The mechanism involves regularized synaptic plasticity and an approximate matching of the temporal dynamics of motor corollary discharge and electrosensory inputs. Recordings of motor corollary discharge signals in mossy fibers and granule cells provide direct evidence for such matching.
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spelling pubmed-64578932019-04-11 Generalization of learned responses in the mormyrid electrosensory lobe Dempsey, Conor Abbott, LF Sawtell, Nathaniel B eLife Neuroscience Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corollary discharge signals cancel responses to the uninformative input evoked by the fish’s own electric pulses. However, for this cancellation to be useful under natural circumstances, it must generalize accurately across behavioral regimes, specifically different electric pulse rates. We show that such generalization indeed occurs in ELL neurons, and develop a circuit-level model explaining how this may be achieved. The mechanism involves regularized synaptic plasticity and an approximate matching of the temporal dynamics of motor corollary discharge and electrosensory inputs. Recordings of motor corollary discharge signals in mossy fibers and granule cells provide direct evidence for such matching. eLife Sciences Publications, Ltd 2019-03-14 /pmc/articles/PMC6457893/ /pubmed/30860480 http://dx.doi.org/10.7554/eLife.44032 Text en © 2019, Dempsey et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Dempsey, Conor
Abbott, LF
Sawtell, Nathaniel B
Generalization of learned responses in the mormyrid electrosensory lobe
title Generalization of learned responses in the mormyrid electrosensory lobe
title_full Generalization of learned responses in the mormyrid electrosensory lobe
title_fullStr Generalization of learned responses in the mormyrid electrosensory lobe
title_full_unstemmed Generalization of learned responses in the mormyrid electrosensory lobe
title_short Generalization of learned responses in the mormyrid electrosensory lobe
title_sort generalization of learned responses in the mormyrid electrosensory lobe
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457893/
https://www.ncbi.nlm.nih.gov/pubmed/30860480
http://dx.doi.org/10.7554/eLife.44032
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