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Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies

While poly(ADP-ribosyl)ation (PARylation) plays an important role in DNA repair, the role of dePARylation in DNA repair remains elusive. Here, we report that a novel small molecule identified from the NCI database, COH34, specifically inhibits poly(ADP-ribose) glycohydrolase (PARG), the major dePARy...

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Detalles Bibliográficos
Autores principales:	Chen, Shih-Hsun, Yu, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457938/ https://www.ncbi.nlm.nih.gov/pubmed/30989114 http://dx.doi.org/10.1126/sciadv.aav4340

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