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Principles of genome folding into topologically associating domains

Understanding the mechanisms that underlie chromosome folding within cell nuclei is essential to determine the relationship between genome structure and function. The recent application of “chromosome conformation capture” techniques has revealed that the genome of many species is organized into dom...

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Detalles Bibliográficos
Autores principales: Szabo, Quentin, Bantignies, Frédéric, Cavalli, Giacomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457944/
https://www.ncbi.nlm.nih.gov/pubmed/30989119
http://dx.doi.org/10.1126/sciadv.aaw1668
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author Szabo, Quentin
Bantignies, Frédéric
Cavalli, Giacomo
author_facet Szabo, Quentin
Bantignies, Frédéric
Cavalli, Giacomo
author_sort Szabo, Quentin
collection PubMed
description Understanding the mechanisms that underlie chromosome folding within cell nuclei is essential to determine the relationship between genome structure and function. The recent application of “chromosome conformation capture” techniques has revealed that the genome of many species is organized into domains of preferential internal chromatin interactions called “topologically associating domains” (TADs). This chromosome chromosome folding has emerged as a key feature of higher-order genome organization and function through evolution. Although TADs have now been described in a wide range of organisms, they appear to have specific characteristics in terms of size, structure, and proteins involved in their formation. Here, we depict the main features of these domains across species and discuss the relation between chromatin structure, genome activity, and epigenome, highlighting mechanistic principles of TAD formation. We also consider the potential influence of TADs in genome evolution.
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spelling pubmed-64579442019-04-15 Principles of genome folding into topologically associating domains Szabo, Quentin Bantignies, Frédéric Cavalli, Giacomo Sci Adv Reviews Understanding the mechanisms that underlie chromosome folding within cell nuclei is essential to determine the relationship between genome structure and function. The recent application of “chromosome conformation capture” techniques has revealed that the genome of many species is organized into domains of preferential internal chromatin interactions called “topologically associating domains” (TADs). This chromosome chromosome folding has emerged as a key feature of higher-order genome organization and function through evolution. Although TADs have now been described in a wide range of organisms, they appear to have specific characteristics in terms of size, structure, and proteins involved in their formation. Here, we depict the main features of these domains across species and discuss the relation between chromatin structure, genome activity, and epigenome, highlighting mechanistic principles of TAD formation. We also consider the potential influence of TADs in genome evolution. American Association for the Advancement of Science 2019-04-10 /pmc/articles/PMC6457944/ /pubmed/30989119 http://dx.doi.org/10.1126/sciadv.aaw1668 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Reviews
Szabo, Quentin
Bantignies, Frédéric
Cavalli, Giacomo
Principles of genome folding into topologically associating domains
title Principles of genome folding into topologically associating domains
title_full Principles of genome folding into topologically associating domains
title_fullStr Principles of genome folding into topologically associating domains
title_full_unstemmed Principles of genome folding into topologically associating domains
title_short Principles of genome folding into topologically associating domains
title_sort principles of genome folding into topologically associating domains
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457944/
https://www.ncbi.nlm.nih.gov/pubmed/30989119
http://dx.doi.org/10.1126/sciadv.aaw1668
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