Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive subtype of acute leukemia, the cell of origin of which is considered to be precursors of plasmacytoid dendritic cells (pDCs). Since translocation (6;8)(p21;q24) is a recurrent anomaly for BPDCN, we demonstrate that a pDC-specific...

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Detalles Bibliográficos
Autores principales: Kubota, Sho, Tokunaga, Kenji, Umezu, Tomohiro, Yokomizo-Nakano, Takako, Sun, Yuqi, Oshima, Motohiko, Tan, Kar Tong, Yang, Henry, Kanai, Akinori, Iwanaga, Eisaku, Asou, Norio, Maeda, Takahiro, Nakagata, Naomi, Iwama, Atsushi, Ohyashiki, Kazuma, Osato, Motomi, Sashida, Goro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458132/
https://www.ncbi.nlm.nih.gov/pubmed/30971697
http://dx.doi.org/10.1038/s41467-019-09710-z

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