Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

The clinical impact of drug-drug interactions based on time-dependent inhibition of cytochrome P450 (CYP) 3A4 has often been overpredicted, likely due to use of improper inhibitor concentration estimates at the enzyme. Here, we investigated if use of cytosolic unbound inhibitor concentrations could...

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Detalles Bibliográficos
Autores principales: Filppula, Anne M., Parvizi, Rezvan, Mateus, André, Baranczewski, Pawel, Artursson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458156/
https://www.ncbi.nlm.nih.gov/pubmed/30971754
http://dx.doi.org/10.1038/s41598-019-42051-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458156/
https://www.ncbi.nlm.nih.gov/pubmed/30971754
http://dx.doi.org/10.1038/s41598-019-42051-x

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