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Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates

Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for alle...

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Autores principales: Gayen nee’ Betal, Suhita, Murthy, Swati, Favara, Michael, Fong, Gina, Chan, Joanna S. Y., Addya, Sankar, Shaffer, Thomas H., Greenspan, Jay, Bhandari, Vineet, Rahman, Irfan, Aghai, Zubair H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458165/
https://www.ncbi.nlm.nih.gov/pubmed/30971730
http://dx.doi.org/10.1038/s41598-019-42205-x
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author Gayen nee’ Betal, Suhita
Murthy, Swati
Favara, Michael
Fong, Gina
Chan, Joanna S. Y.
Addya, Sankar
Shaffer, Thomas H.
Greenspan, Jay
Bhandari, Vineet
Rahman, Irfan
Aghai, Zubair H.
author_facet Gayen nee’ Betal, Suhita
Murthy, Swati
Favara, Michael
Fong, Gina
Chan, Joanna S. Y.
Addya, Sankar
Shaffer, Thomas H.
Greenspan, Jay
Bhandari, Vineet
Rahman, Irfan
Aghai, Zubair H.
author_sort Gayen nee’ Betal, Suhita
collection PubMed
description Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and asthma later in childhood, the mechanism(s) of which are still not yet well understood. The objective of this study was to determine the mRNA transcriptome of cord blood mononuclear leukocytes from term neonates to identify key genes and pathways involved in HCA. We found 366 differentially expressed probe IDs with exposure to HCA (198 upregulated, 168 downregulated). These transcriptomes included novel genes and pathways associated with exposure to HCA. The differential gene expression included key genes regulating inflammatory, immune, respiratory and neurological pathways, which may contribute to disorders in those pathways in neonates exposed to HCA. Our data may lead to understanding of the role of key genes and pathways identified on the long-term sequelae related to exposure to HCA, as well as to identifying potential markers and therapies to prevent HCA-associated complications.
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spelling pubmed-64581652019-04-15 Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates Gayen nee’ Betal, Suhita Murthy, Swati Favara, Michael Fong, Gina Chan, Joanna S. Y. Addya, Sankar Shaffer, Thomas H. Greenspan, Jay Bhandari, Vineet Rahman, Irfan Aghai, Zubair H. Sci Rep Article Histological chorioamnionitis (HCA) is an infection of fetal membranes and complicates 5.2% to 28.5% of all live births. HCA is associated with increased mortality and morbidity in both premature and term neonates. Exposure to HCA may have long-term consequences, including an increased risk for allergic disorders and asthma later in childhood, the mechanism(s) of which are still not yet well understood. The objective of this study was to determine the mRNA transcriptome of cord blood mononuclear leukocytes from term neonates to identify key genes and pathways involved in HCA. We found 366 differentially expressed probe IDs with exposure to HCA (198 upregulated, 168 downregulated). These transcriptomes included novel genes and pathways associated with exposure to HCA. The differential gene expression included key genes regulating inflammatory, immune, respiratory and neurological pathways, which may contribute to disorders in those pathways in neonates exposed to HCA. Our data may lead to understanding of the role of key genes and pathways identified on the long-term sequelae related to exposure to HCA, as well as to identifying potential markers and therapies to prevent HCA-associated complications. Nature Publishing Group UK 2019-04-10 /pmc/articles/PMC6458165/ /pubmed/30971730 http://dx.doi.org/10.1038/s41598-019-42205-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gayen nee’ Betal, Suhita
Murthy, Swati
Favara, Michael
Fong, Gina
Chan, Joanna S. Y.
Addya, Sankar
Shaffer, Thomas H.
Greenspan, Jay
Bhandari, Vineet
Rahman, Irfan
Aghai, Zubair H.
Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates
title Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates
title_full Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates
title_fullStr Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates
title_full_unstemmed Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates
title_short Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates
title_sort histological chorioamnionitis induces differential gene expression in human cord blood mononuclear leukocytes from term neonates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458165/
https://www.ncbi.nlm.nih.gov/pubmed/30971730
http://dx.doi.org/10.1038/s41598-019-42205-x
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