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Dexamethasone Predisposes Human Erythroblasts Toward Impaired Lipid Metabolism and Renders Their ex vivo Expansion Highly Dependent on Plasma Lipoproteins

Cultures of stem cells from discarded sources supplemented with dexamethasone, a synthetic glucocorticoid receptor agonist, generate cultured red blood cells (cRBCs) in numbers sufficient for transfusion. According to the literature, however, erythroblasts generated with dexamethasone exhibit low en...

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Detalles Bibliográficos
Autores principales: Zingariello, Maria, Bardelli, Claudio, Sancillo, Laura, Ciaffoni, Fiorella, Genova, Maria Luisa, Girelli, Gabriella, Migliaccio, Anna Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458278/
https://www.ncbi.nlm.nih.gov/pubmed/31019464
http://dx.doi.org/10.3389/fphys.2019.00281