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The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system

Succinate dehydrogenase (SDH) is a mitochondrial enzyme that plays an important role in both the Krebs cycle and the electron transport chain. SDH inactivation is associated with tumorigenesis in certain types of tumor. SDH consists of subunits A, B, C and D (SDHA, SDHB, SDHC, and SDHD, respectively...

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Autores principales: Roh, Tae Hoon, Yim, Hyunee, Roh, Jin, Lee, Kyi Beom, Park, So Hyun, Jeong, Seon-Yong, Kim, Se-Hyuk, Kim, Jang-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458311/
https://www.ncbi.nlm.nih.gov/pubmed/30971719
http://dx.doi.org/10.1038/s41598-019-42338-z
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author Roh, Tae Hoon
Yim, Hyunee
Roh, Jin
Lee, Kyi Beom
Park, So Hyun
Jeong, Seon-Yong
Kim, Se-Hyuk
Kim, Jang-Hee
author_facet Roh, Tae Hoon
Yim, Hyunee
Roh, Jin
Lee, Kyi Beom
Park, So Hyun
Jeong, Seon-Yong
Kim, Se-Hyuk
Kim, Jang-Hee
author_sort Roh, Tae Hoon
collection PubMed
description Succinate dehydrogenase (SDH) is a mitochondrial enzyme that plays an important role in both the Krebs cycle and the electron transport chain. SDH inactivation is associated with tumorigenesis in certain types of tumor. SDH consists of subunits A, B, C and D (SDHA, SDHB, SDHC, and SDHD, respectively). Immunohistochemistry for SDHB is a reliable method for detecting the inactivation of SDH by mutations in SDHA, SDHB, SDHC, SDHD and SDH complex assembly factor 2 (SDHAF2) genes with high sensitivity and specificity. SDHB immunohistochemistry has been used to examine the inactivation of SDH in various types of tumors. However, data on central nervous system (CNS) tumors are very limited. In the present study, we investigated the loss of SDHB immunoexpression in 90 cases of CNS tumors. Among the 90 cases of CNS tumors, only three cases of hemangioblastoma showed loss of SDHB immunoexpression. We further investigated SDHB immunoexpression in 35 cases of hemangioblastoma and found that 28 (80%) showed either negative or weak-diffuse pattern of SDHB immunoexpression, which suggests the inactivation of SDH. Our results suggest that SDH inactivation may represent an alternative pathway in the tumorigenesis of hemangioblastoma.
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spelling pubmed-64583112019-04-16 The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system Roh, Tae Hoon Yim, Hyunee Roh, Jin Lee, Kyi Beom Park, So Hyun Jeong, Seon-Yong Kim, Se-Hyuk Kim, Jang-Hee Sci Rep Article Succinate dehydrogenase (SDH) is a mitochondrial enzyme that plays an important role in both the Krebs cycle and the electron transport chain. SDH inactivation is associated with tumorigenesis in certain types of tumor. SDH consists of subunits A, B, C and D (SDHA, SDHB, SDHC, and SDHD, respectively). Immunohistochemistry for SDHB is a reliable method for detecting the inactivation of SDH by mutations in SDHA, SDHB, SDHC, SDHD and SDH complex assembly factor 2 (SDHAF2) genes with high sensitivity and specificity. SDHB immunohistochemistry has been used to examine the inactivation of SDH in various types of tumors. However, data on central nervous system (CNS) tumors are very limited. In the present study, we investigated the loss of SDHB immunoexpression in 90 cases of CNS tumors. Among the 90 cases of CNS tumors, only three cases of hemangioblastoma showed loss of SDHB immunoexpression. We further investigated SDHB immunoexpression in 35 cases of hemangioblastoma and found that 28 (80%) showed either negative or weak-diffuse pattern of SDHB immunoexpression, which suggests the inactivation of SDH. Our results suggest that SDH inactivation may represent an alternative pathway in the tumorigenesis of hemangioblastoma. Nature Publishing Group UK 2019-04-10 /pmc/articles/PMC6458311/ /pubmed/30971719 http://dx.doi.org/10.1038/s41598-019-42338-z Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Roh, Tae Hoon
Yim, Hyunee
Roh, Jin
Lee, Kyi Beom
Park, So Hyun
Jeong, Seon-Yong
Kim, Se-Hyuk
Kim, Jang-Hee
The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
title The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
title_full The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
title_fullStr The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
title_full_unstemmed The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
title_short The loss of succinate dehydrogenase B expression is frequently identified in hemangioblastoma of the central nervous system
title_sort loss of succinate dehydrogenase b expression is frequently identified in hemangioblastoma of the central nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458311/
https://www.ncbi.nlm.nih.gov/pubmed/30971719
http://dx.doi.org/10.1038/s41598-019-42338-z
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