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Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 me...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458458/ https://www.ncbi.nlm.nih.gov/pubmed/31008364 http://dx.doi.org/10.1002/edm2.56 |
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author | Alsalim, Wathik Ahrén, Bo |
author_facet | Alsalim, Wathik Ahrén, Bo |
author_sort | Alsalim, Wathik |
collection | PubMed |
description | People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects. |
format | Online Article Text |
id | pubmed-6458458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64584582019-04-19 Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects Alsalim, Wathik Ahrén, Bo Endocrinol Diabetes Metab Original Articles People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects. John Wiley and Sons Inc. 2019-01-17 /pmc/articles/PMC6458458/ /pubmed/31008364 http://dx.doi.org/10.1002/edm2.56 Text en © 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Alsalim, Wathik Ahrén, Bo Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
title | Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
title_full | Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
title_fullStr | Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
title_full_unstemmed | Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
title_short | Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
title_sort | insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458458/ https://www.ncbi.nlm.nih.gov/pubmed/31008364 http://dx.doi.org/10.1002/edm2.56 |
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