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Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects

People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 me...

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Detalles Bibliográficos
Autores principales: Alsalim, Wathik, Ahrén, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458458/
https://www.ncbi.nlm.nih.gov/pubmed/31008364
http://dx.doi.org/10.1002/edm2.56
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author Alsalim, Wathik
Ahrén, Bo
author_facet Alsalim, Wathik
Ahrén, Bo
author_sort Alsalim, Wathik
collection PubMed
description People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects.
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spelling pubmed-64584582019-04-19 Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects Alsalim, Wathik Ahrén, Bo Endocrinol Diabetes Metab Original Articles People with repeated rapid meal ingestion have been reported to have increased risk of insulin resistance, impaired glucose tolerance and obesity. To explore whether speed of eating a breakfast influences the postprandial rise of glucose, insulin and the incretin hormones, 24 healthy subjects (12 men and 12 women, mean age 62 years) ingested a standardized solid breakfast consisting of 524 kcal (60% from carbohydrate, 20% from protein, 20% from fat) over 5 or 12 minutes on separate days in random order. Breakfast ingestion increased circulating glucose and insulin with maximal levels seen at 30 minutes after start of meal ingestion with no significant difference in the two tests. Similarly, breakfast increased circulating levels of total (reflecting secretion) glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) with, again, no difference between the tests. Furthermore, gastric emptying, as revealed by the indirect paracetamol test, did not differ between the tests. We therefore conclude that the speed of breakfast ingestion does not affect the postprandial rise of glucose, insulin or incretin hormones in healthy subjects. John Wiley and Sons Inc. 2019-01-17 /pmc/articles/PMC6458458/ /pubmed/31008364 http://dx.doi.org/10.1002/edm2.56 Text en © 2019 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Alsalim, Wathik
Ahrén, Bo
Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
title Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
title_full Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
title_fullStr Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
title_full_unstemmed Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
title_short Insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
title_sort insulin and incretin hormone responses to rapid versus slow ingestion of a standardized solid breakfast in healthy subjects
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458458/
https://www.ncbi.nlm.nih.gov/pubmed/31008364
http://dx.doi.org/10.1002/edm2.56
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