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Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children. STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were perfo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458483/ https://www.ncbi.nlm.nih.gov/pubmed/31008362 http://dx.doi.org/10.1002/edm2.54 |
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author | Blain, Hailey Sinaii, Ninet Zeltser, Deena Lyssikatos, Charalampos Belyavskaya, Elena Keil, Margaret Bluemke, David A. Stratakis, Constantine Bandettini, Wiphada Patricia Lodish, Maya |
author_facet | Blain, Hailey Sinaii, Ninet Zeltser, Deena Lyssikatos, Charalampos Belyavskaya, Elena Keil, Margaret Bluemke, David A. Stratakis, Constantine Bandettini, Wiphada Patricia Lodish, Maya |
author_sort | Blain, Hailey |
collection | PubMed |
description | OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children. STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were performed on 18 children with CS (mean: 12.5 ± 3.1 years, range: 6.0‐16.8 years, 10 female). Pulse wave velocity (PWV), aortic distensibility (AD) and carotid intima‐media thickness (cIMT), well‐validated measurements of cardiac compromise, were measured from the images and compared to normative age‐matched values where available. RESULTS: Patients with CS had significantly higher PWV compared to age‐adjusted normal median control values (4.0 ± 0.7 m/s vs. 3.4 ± 0.2 m/s, respectively, P = 0.0115). PWV was positively correlated with midnight plasma cortisol (r = 0.56, P = 0.02). Internal and common cIMT were negatively correlated with ascending AD (r = −0.75, P = 0.0022, r = −0.69, P = 0.0068, respectively). CONCLUSION: Pulse wave velocity data indicate that paediatric patients with CS have early evidence of cardiovascular remodelling. The results suggest the opportunity for monitoring as these changes begin in childhood. |
format | Online Article Text |
id | pubmed-6458483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64584832019-04-19 Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease Blain, Hailey Sinaii, Ninet Zeltser, Deena Lyssikatos, Charalampos Belyavskaya, Elena Keil, Margaret Bluemke, David A. Stratakis, Constantine Bandettini, Wiphada Patricia Lodish, Maya Endocrinol Diabetes Metab Original Articles OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children. STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were performed on 18 children with CS (mean: 12.5 ± 3.1 years, range: 6.0‐16.8 years, 10 female). Pulse wave velocity (PWV), aortic distensibility (AD) and carotid intima‐media thickness (cIMT), well‐validated measurements of cardiac compromise, were measured from the images and compared to normative age‐matched values where available. RESULTS: Patients with CS had significantly higher PWV compared to age‐adjusted normal median control values (4.0 ± 0.7 m/s vs. 3.4 ± 0.2 m/s, respectively, P = 0.0115). PWV was positively correlated with midnight plasma cortisol (r = 0.56, P = 0.02). Internal and common cIMT were negatively correlated with ascending AD (r = −0.75, P = 0.0022, r = −0.69, P = 0.0068, respectively). CONCLUSION: Pulse wave velocity data indicate that paediatric patients with CS have early evidence of cardiovascular remodelling. The results suggest the opportunity for monitoring as these changes begin in childhood. John Wiley and Sons Inc. 2019-01-15 /pmc/articles/PMC6458483/ /pubmed/31008362 http://dx.doi.org/10.1002/edm2.54 Text en Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Blain, Hailey Sinaii, Ninet Zeltser, Deena Lyssikatos, Charalampos Belyavskaya, Elena Keil, Margaret Bluemke, David A. Stratakis, Constantine Bandettini, Wiphada Patricia Lodish, Maya Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease |
title | Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease |
title_full | Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease |
title_fullStr | Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease |
title_full_unstemmed | Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease |
title_short | Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease |
title_sort | aortic pulse wave velocity in children with cushing syndrome: a window into a marker of early cardiovascular disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458483/ https://www.ncbi.nlm.nih.gov/pubmed/31008362 http://dx.doi.org/10.1002/edm2.54 |
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