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Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease

OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children. STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were perfo...

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Autores principales: Blain, Hailey, Sinaii, Ninet, Zeltser, Deena, Lyssikatos, Charalampos, Belyavskaya, Elena, Keil, Margaret, Bluemke, David A., Stratakis, Constantine, Bandettini, Wiphada Patricia, Lodish, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458483/
https://www.ncbi.nlm.nih.gov/pubmed/31008362
http://dx.doi.org/10.1002/edm2.54
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author Blain, Hailey
Sinaii, Ninet
Zeltser, Deena
Lyssikatos, Charalampos
Belyavskaya, Elena
Keil, Margaret
Bluemke, David A.
Stratakis, Constantine
Bandettini, Wiphada Patricia
Lodish, Maya
author_facet Blain, Hailey
Sinaii, Ninet
Zeltser, Deena
Lyssikatos, Charalampos
Belyavskaya, Elena
Keil, Margaret
Bluemke, David A.
Stratakis, Constantine
Bandettini, Wiphada Patricia
Lodish, Maya
author_sort Blain, Hailey
collection PubMed
description OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children. STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were performed on 18 children with CS (mean: 12.5 ± 3.1 years, range: 6.0‐16.8 years, 10 female). Pulse wave velocity (PWV), aortic distensibility (AD) and carotid intima‐media thickness (cIMT), well‐validated measurements of cardiac compromise, were measured from the images and compared to normative age‐matched values where available. RESULTS: Patients with CS had significantly higher PWV compared to age‐adjusted normal median control values (4.0 ± 0.7 m/s vs. 3.4 ± 0.2 m/s, respectively, P = 0.0115). PWV was positively correlated with midnight plasma cortisol (r = 0.56, P = 0.02). Internal and common cIMT were negatively correlated with ascending AD (r = −0.75, P = 0.0022, r = −0.69, P = 0.0068, respectively). CONCLUSION: Pulse wave velocity data indicate that paediatric patients with CS have early evidence of cardiovascular remodelling. The results suggest the opportunity for monitoring as these changes begin in childhood.
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spelling pubmed-64584832019-04-19 Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease Blain, Hailey Sinaii, Ninet Zeltser, Deena Lyssikatos, Charalampos Belyavskaya, Elena Keil, Margaret Bluemke, David A. Stratakis, Constantine Bandettini, Wiphada Patricia Lodish, Maya Endocrinol Diabetes Metab Original Articles OBJECTIVE: To investigate early signs of cardiovascular arterial remodelling in paediatric patients with Cushing syndrome (CS) in comparison with normative values from healthy children. STUDY DESIGN: The metrics used to assess cardiac health were from thoracic aorta and carotid MRI. Scans were performed on 18 children with CS (mean: 12.5 ± 3.1 years, range: 6.0‐16.8 years, 10 female). Pulse wave velocity (PWV), aortic distensibility (AD) and carotid intima‐media thickness (cIMT), well‐validated measurements of cardiac compromise, were measured from the images and compared to normative age‐matched values where available. RESULTS: Patients with CS had significantly higher PWV compared to age‐adjusted normal median control values (4.0 ± 0.7 m/s vs. 3.4 ± 0.2 m/s, respectively, P = 0.0115). PWV was positively correlated with midnight plasma cortisol (r = 0.56, P = 0.02). Internal and common cIMT were negatively correlated with ascending AD (r = −0.75, P = 0.0022, r = −0.69, P = 0.0068, respectively). CONCLUSION: Pulse wave velocity data indicate that paediatric patients with CS have early evidence of cardiovascular remodelling. The results suggest the opportunity for monitoring as these changes begin in childhood. John Wiley and Sons Inc. 2019-01-15 /pmc/articles/PMC6458483/ /pubmed/31008362 http://dx.doi.org/10.1002/edm2.54 Text en Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Blain, Hailey
Sinaii, Ninet
Zeltser, Deena
Lyssikatos, Charalampos
Belyavskaya, Elena
Keil, Margaret
Bluemke, David A.
Stratakis, Constantine
Bandettini, Wiphada Patricia
Lodish, Maya
Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
title Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
title_full Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
title_fullStr Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
title_full_unstemmed Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
title_short Aortic pulse wave velocity in children with Cushing syndrome: A window into a marker of early cardiovascular disease
title_sort aortic pulse wave velocity in children with cushing syndrome: a window into a marker of early cardiovascular disease
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458483/
https://www.ncbi.nlm.nih.gov/pubmed/31008362
http://dx.doi.org/10.1002/edm2.54
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